Nikzamir Abdolrahim, Rashidi Armin, Esteghamati Alireza, Nakhjavani Manouchehr, Golmohammadi Taghi, Khalilzadeh Omid
Department of Biochemistry, Ahwaz Jondi Shapour University of Medical Sciences, Ahwaz, Iran.
Ophthalmic Genet. 2010 Sep;31(3):108-13. doi: 10.3109/13816810.2010.482554.
The role of genetic factors in diabetic retinopathy (DR) is unclear. We investigated the relationship between DR and an insertion/deletion polymorphism in the angiotensin-converting enzyme (ACE) gene in Iranian patients with type 2 diabetes without overt nephropathy.
A total of 178 consecutive type 2 diabetic patients with DR (Group A) and 206 type 2 diabetic patients without DR (Group B) were studied. The following variables were determined: age, sex, body mass index, diabetes duration, medications used, history of coronary artery disease and its complications, blood pressure (systolic and diastolic), fasting plasma glucose, hemoglobin A1c, total cholesterol, low- and high-density lipoproteins, triglycerides, plasma creatinine, and 24-h urine albumin excretion.
The groups were statistically similar in all variables except diabetes duration (P = 0.037), ACE activity (P < 0.001), and ACE genotype (P = 0.008). The DD genotype was significantly more common in Group A (32.6% versus 19.2% in Group B; P = 0.009). In multivariate regression analysis, the ID genotype (compared to the II genotype) was an independent predictor of DR (OR = 1.831, 95% CI = 1.074-3.124; P = 0.026).
The D allele of the ACE gene is independently associated with DR in Iranian type 2 diabetic patients.
遗传因素在糖尿病视网膜病变（DR）中的作用尚不清楚。我们研究了伊朗2型糖尿病且无明显肾病患者中DR与血管紧张素转换酶（ACE）基因插入/缺失多态性之间的关系。
共研究了178例连续性2型糖尿病DR患者（A组）和206例无DR的2型糖尿病患者（B组）。测定了以下变量：年龄、性别、体重指数、糖尿病病程、用药情况、冠状动脉疾病及其并发症史、血压（收缩压和舒张压）、空腹血糖、糖化血红蛋白、总胆固醇、低密度和高密度脂蛋白、甘油三酯、血肌酐以及24小时尿白蛋白排泄量。
除糖尿病病程（P = 0.037）、ACE活性（P < 0.001）和ACE基因型（P = 0.008）外，两组在所有变量上均无统计学差异。DD基因型在A组中显著更常见（A组为32.6%，B组为19.2%；P = 0.009）。在多因素回归分析中，ID基因型（与II基因型相比）是DR的独立预测因素（OR = 1.831，95%CI = 1.074 - 3.124；P = 0.026）。
在伊朗2型糖尿病患者中，ACE基因的D等位基因与DR独立相关。
