伊朗2型糖尿病患者中ACE基因插入/缺失多态性与糖尿病视网膜病变的关系。

The relationship between ACE gene insertion/deletion polymorphism and diabetic retinopathy in Iranian patients with type 2 diabetes.

作者信息

Nikzamir Abdolrahim, Rashidi Armin, Esteghamati Alireza, Nakhjavani Manouchehr, Golmohammadi Taghi, Khalilzadeh Omid

机构信息

Department of Biochemistry, Ahwaz Jondi Shapour University of Medical Sciences, Ahwaz, Iran.

出版信息

Ophthalmic Genet. 2010 Sep;31(3):108-13. doi: 10.3109/13816810.2010.482554.

DOI:10.3109/13816810.2010.482554

PMID:20565247

Abstract

BACKGROUND

The role of genetic factors in diabetic retinopathy (DR) is unclear. We investigated the relationship between DR and an insertion/deletion polymorphism in the angiotensin-converting enzyme (ACE) gene in Iranian patients with type 2 diabetes without overt nephropathy.

METHODS

A total of 178 consecutive type 2 diabetic patients with DR (Group A) and 206 type 2 diabetic patients without DR (Group B) were studied. The following variables were determined: age, sex, body mass index, diabetes duration, medications used, history of coronary artery disease and its complications, blood pressure (systolic and diastolic), fasting plasma glucose, hemoglobin A1c, total cholesterol, low- and high-density lipoproteins, triglycerides, plasma creatinine, and 24-h urine albumin excretion.

RESULTS

The groups were statistically similar in all variables except diabetes duration (P = 0.037), ACE activity (P < 0.001), and ACE genotype (P = 0.008). The DD genotype was significantly more common in Group A (32.6% versus 19.2% in Group B; P = 0.009). In multivariate regression analysis, the ID genotype (compared to the II genotype) was an independent predictor of DR (OR = 1.831, 95% CI = 1.074-3.124; P = 0.026).

CONCLUSIONS

The D allele of the ACE gene is independently associated with DR in Iranian type 2 diabetic patients.

摘要

背景

遗传因素在糖尿病视网膜病变（DR）中的作用尚不清楚。我们研究了伊朗2型糖尿病且无明显肾病患者中DR与血管紧张素转换酶（ACE）基因插入/缺失多态性之间的关系。

方法

共研究了178例连续性2型糖尿病DR患者（A组）和206例无DR的2型糖尿病患者（B组）。测定了以下变量：年龄、性别、体重指数、糖尿病病程、用药情况、冠状动脉疾病及其并发症史、血压（收缩压和舒张压）、空腹血糖、糖化血红蛋白、总胆固醇、低密度和高密度脂蛋白、甘油三酯、血肌酐以及24小时尿白蛋白排泄量。

结果

除糖尿病病程（P = 0.037）、ACE活性（P < 0.001）和ACE基因型（P = 0.008）外，两组在所有变量上均无统计学差异。DD基因型在A组中显著更常见（A组为32.6%，B组为19.2%；P = 0.009）。在多因素回归分析中，ID基因型（与II基因型相比）是DR的独立预测因素（OR = 1.831，95%CI = 1.074 - 3.124；P = 0.026）。