Oliver David J, Campbell Colin, O'brien Tony, Sloan Richard, Sykes Nigel, Tallon Carol, Taylor-Horan Jane, Udoma Mayen
Wisdom Hospice, University of Kent, High Bank, Rochester, Kent, UK.
Amyotroph Lateral Scler. 2010 Dec;11(6):562-4. doi: 10.3109/17482968.2010.493203. Epub 2010 Jun 22.
Our objective was to study the use of opioid and other medication at the end of life for patients with ALS/MND under specialist palliative care. A retrospective study looked at the medication received by 62 patients with MND/ALS in the last 72 h of life in six hospices in the UK and Ireland. Medication is widely used in the last 24 h of life, and use of the parenteral route increases as death approaches. We found that the doses of opioids and other medication do not increase appreciably during this period. The mean dose of opioid in the last 24 h of life was 80 mg oral morphine equivalent/24 h. These results are further evidence that opioids can be used both effectively and safely to manage symptoms at the end of life for people with MND/ALS.
我们的目标是研究在专科姑息治疗下，肌萎缩侧索硬化症/运动神经元病（ALS/MND）患者临终时阿片类药物及其他药物的使用情况。一项回顾性研究观察了英国和爱尔兰6家临终关怀机构中62例运动神经元病/肌萎缩侧索硬化症（MND/ALS）患者在生命的最后72小时所接受的药物治疗。药物在生命的最后24小时被广泛使用，并且随着死亡临近，肠外给药途径的使用增加。我们发现，在此期间阿片类药物和其他药物的剂量并未显著增加。生命最后24小时阿片类药物的平均剂量为80毫克口服吗啡等效物/24小时。这些结果进一步证明，阿片类药物可有效且安全地用于控制MND/ALS患者临终时的症状。
