Oliver D
Wisdom Hospice, Rochester, Kent, UK.
Palliat Med. 1998 Mar;12(2):113-5. doi: 10.1191/026921698677326556.
In the palliative care of patients with motor neurone disease (MND) symptoms are encountered that can be helped by the use of strong opioid medication. A retrospective survey of the 32 patients dying of MND at the Wisdom Hospice who required opioids showed that 75% received oral opioids, 94% received parenteral opioids and 72% received both oral and parenteral opioids. The median oral morphine dose was 60 mg/24 h, with a median duration of 51 days and the median parenteral dose was 180 mg/24 h with a median duration of use of three days. The results show that strong opioids can be used safely and effectively in the palliative care of patients with MND.
在运动神经元病（MND）患者的姑息治疗中，会出现一些可通过使用强效阿片类药物得到缓解的症状。对智慧临终关怀院32例死于MND且需要使用阿片类药物的患者进行的回顾性调查显示，75%的患者接受口服阿片类药物，94%的患者接受胃肠外阿片类药物，72%的患者同时接受口服和胃肠外阿片类药物。口服吗啡的中位剂量为60毫克/24小时，中位使用时长为51天，胃肠外给药的中位剂量为180毫克/24小时，中位使用时长为3天。结果表明，强效阿片类药物可安全有效地用于MND患者的姑息治疗。
