Grazi Enrico, Pozzati Sara
Dipartimento di Biochimica e Biologia Molecolare, Università di Ferrara, Via Borsari 46, 44100, Ferrara, Italy.
Theor Biol Med Model. 2010 Jun 18;7(1):24. doi: 10.1186/1742-4682-7-24.
The scope of this work is to show that the correct and complete definition of the system of muscle contraction requires the knowledge of both the mass and the acceleration of the load.
The aim is achieved by making use of a model of muscle contraction that operates into two phases. The first phase considers the effects of the power stroke in the absence of any hindrance. In the second phase viscous hindrance is introduced to match the experimental speed and yield of the contraction. It is shown that, at constant force of the load, changing load acceleration changes the time course of the pre-steady state of myofibril contraction. The decrease of the acceleration of the load from 9.8 m.s(-2) to 1 m.s(-2) increases the time length of the pre-steady state of the contraction from a few microseconds to many hundreds of microseconds and decreases the stiffness of the active fibre.
We urge that in the study of muscle contraction both the mass and the acceleration of the load are specified.
本研究的范围是表明肌肉收缩系统的正确和完整定义需要了解负荷的质量和加速度。
通过使用一个分两个阶段运行的肌肉收缩模型实现了这一目标。第一阶段考虑了在没有任何阻碍的情况下动力冲程的影响。在第二阶段引入粘性阻碍以匹配收缩的实验速度和产率。结果表明，在负荷力恒定的情况下，改变负荷加速度会改变肌原纤维收缩预稳态的时间进程。负荷加速度从9.8 m·s⁻²降至1 m·s⁻²会使收缩预稳态的时间长度从几微秒增加到数百微秒，并降低活性纤维的刚度。
我们敦促在肌肉收缩研究中明确负荷的质量和加速度。
