宫颈癌患者外周循环中树突状细胞亚群的改变。

Women's Reproductive Health Key Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Xueshi Rd#2, Hangzhou, 310006, China.

J Exp Clin Cancer Res. 2010 Jun 18;29(1):78. doi: 10.1186/1756-9966-29-78.

Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma (CC), 54 patients with CIN, and 62 healthy individuals. A substantial reduction of circulating dendritic cells and accordingly immunodepression may be associated with increased IL-6 and TGF-beta in serum. These findings could give expression to the immunosuppression of circulating dendritic cells in patients with CC and CIN, thus, may indicate novel aspects of cervical carcinoma immune evasion.

患有宫颈癌（CC）的患者通常免疫功能低下。树突状细胞（DC）是强有力的抗原呈递细胞。通过多色流式细胞术，测定了 37 例宫颈癌（CC）患者、54 例宫颈上皮内瘤变（CIN）患者和 62 例健康个体外周血中 CD11c+（DC1）和 CD123+（DC2）亚群的百分比。循环树突状细胞的大量减少和相应的免疫抑制可能与血清中 IL-6 和 TGF-β的增加有关。这些发现可以表达 CC 和 CIN 患者循环树突状细胞的免疫抑制，因此，可能提示宫颈癌免疫逃逸的新方面。