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机器人前列腺切除术后早期尿失禁的预测因素。

Predictors of early urinary continence after robotic prostatectomy.

作者信息

Lee Daniel J, Cheetham Philippa, Badani Ketan K

机构信息

Department of Urology, Columbia University Medical Center, New York, New York 10032, USA.

出版信息

Can J Urol. 2010 Jun;17(3):5200-5.

Abstract

OBJECTIVE

We sought to identify predictors of early urinary continence after robot-assisted prostatectomy (RARP) in men who underwent a posterior rhabdosphincter reconstruction.

MATERIALS AND METHODS

A prospective analysis was performed in 107 consecutive men who underwent RARP by a single surgeon in an academic center. Men were excluded if they received adjuvant radiation therapy (7 men), were lost to follow up (4), or did not have a posterior rhabdosphincter reconstruction (8 men). Eighty-eight men received a posterior rhabdosphincter reconstruction and were followed in this study. Patient demographic and postoperative urinary control was recorded at interval follow up visits by the physician and research staff. Level of comorbidity was measured with the Charlson Comorbidity Index (CACI). Preoperative urinary function was measured using the International Prostate Symptom Score (IPSS). Continence was defined as men using zero pads per day.

RESULTS

Eighty-eight men with a mean age of 59.2 years (43.1-77.6) were followed for a median of 7.6 (range 1.5-16.7) months. The median preoperative PSA and IPSS was 5.0 ng/mL (range 0.95 ng/mL-23 ng/mL) and 8 (range 0-30), respectively. Overall, 91% of the men achieved continence with a median time to continence of 2.3 months. Of those, 50% achieved continence by 6 weeks. Men continent at 6 weeks were significantly younger, had lower IPSS scores, and less comorbidities (p = 0.01). Age (OR = 0.91, p < 0.01) and higher IPSS scores (OR = 0.28, p = 0.03) were associated with decreased odds of achieving continence at 6 weeks. The presence of coexisting disease was not predictive of continence return. After adjusting for comorbidity, body mass index (BMI), nerve sparing, and IPSS score, only age remained as an independent predictor of early continence (OR = 0.90, p = 0.04).

CONCLUSIONS

In conclusion, we found that increased age and increased lower urinary tract symptom (LUTS) severity are associated with decreased odds of achieving continence 6 weeks after RARP. Patient age remains the strongest predictor of early return of continence in a multivariate model. These factors should be used in counseling prior to surgery to meet realistic patient expectations.

摘要

目的

我们试图确定接受后尿道括约肌重建术的男性在机器人辅助前列腺切除术后(RARP)早期实现尿控的预测因素。

材料与方法

对在一所学术中心由一名外科医生连续进行RARP手术的107名男性进行前瞻性分析。如果患者接受辅助放疗(7名男性)、失访(4名)或未进行后尿道括约肌重建(8名男性),则将其排除。88名男性接受了后尿道括约肌重建并纳入本研究。在随访期间,由医生和研究人员记录患者的人口统计学资料和术后尿控情况。使用Charlson合并症指数(CACI)测量合并症水平。术前使用国际前列腺症状评分(IPSS)评估排尿功能。尿控定义为男性每天使用零片尿垫。

结果

88名平均年龄为59.2岁(43.1 - 77.6岁)的男性,中位随访时间为7.6个月(范围1.5 - 16.7个月)。术前PSA和IPSS的中位数分别为5.0 ng/mL(范围0.95 ng/mL - 23 ng/mL)和8(范围0 - 30)。总体而言,91%的男性实现了尿控,中位尿控时间为2.3个月。其中,50%的男性在6周时实现了尿控。在6周时实现尿控的男性明显更年轻,IPSS评分更低,合并症更少(p = 0.01)。年龄(OR = 0.91,p < 0.01)和较高的IPSS评分(OR = 0.28,p = 0.03)与6周时实现尿控的几率降低相关。并存疾病的存在并不能预测尿控恢复情况。在对合并症、体重指数(BMI)、保留神经情况和IPSS评分进行调整后,只有年龄仍然是早期尿控的独立预测因素(OR = 0.90,p = 0.04)。

结论

总之,我们发现年龄增加和下尿路症状(LUTS)严重程度增加与RARP术后6周实现尿控的几率降低相关。在多变量模型中,患者年龄仍然是尿控早期恢复的最强预测因素。这些因素应在手术前用于咨询,以满足患者的现实期望。

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