Polymer Engineering Group, Faculty of Engineering, Tarbiat Modares University, PO Box 14115-143, Tehran, I R Iran.
J Biomater Sci Polym Ed. 2011;22(8):1023-33. doi: 10.1163/092050610X497881. Epub 2010 Jun 21.
In the present work, a nanocomposite hydrogel wound dressing was prepared on the basis of poly(vinyl alcohol) using organically-modified montmorillonite as nanoclay by the freezing-thawing cyclic method. In vivo assays were performed to evaluate its performance as an applicable wound dressing on animals. It showed an improved healing process for wounds covered by the prepared nanocomposite hydrogel compared with control wounds covered by sterile gauze. Significant improvements, such as better creation of moist surfaces on the wound with less scar formation, shorter duration of healing operation and better closing of the wound edges with enhanced tensile properties of the healed wound, i.e., tensile strength and elongation-at-break, were observed using the prepared nanocomposite hydrogel in comparison to the sterile gauze. An in vitro cytotoxic assay was also utilized to determine the biocompatibility of the prepared nanocomposite hydrogel. It showed that the prepared nanocomposite hydrogel is non-toxic and can be used as a biocompatible wound dressing in practical wound management.
在本工作中，通过冷冻-解冻循环法，使用有机改性蒙脱土作为纳米粘土，在聚乙烯醇的基础上制备了纳米复合水凝胶创伤敷料。进行了体内试验以评估其作为动物适用的创伤敷料的性能。与用无菌纱布覆盖的对照伤口相比，用制备的纳米复合水凝胶覆盖的伤口的愈合过程得到了改善。与无菌纱布相比，使用制备的纳米复合水凝胶观察到显著的改善，例如在伤口上形成更好的湿润表面，减少疤痕形成，愈合操作持续时间更短，以及通过提高愈合伤口的拉伸性能更好地闭合伤口边缘，即拉伸强度和断裂伸长率。还利用体外细胞毒性试验来确定制备的纳米复合水凝胶的生物相容性。结果表明，制备的纳米复合水凝胶是无毒的，可以用作实际伤口管理中的生物相容的创伤敷料。
