Tong Sen, Li Qingyu, Liu Qiaoyan, Song Bo, Wu Junzi
School of Basic Medical, Yunnan University of Chinese Medicine, Kunming, Yunnan, China.
School of Medicine, Jianghan University, Wuhan, China.
Front Bioeng Biotechnol. 2022 Oct 4;10:1039495. doi: 10.3389/fbioe.2022.1039495. eCollection 2022.
Diabetic ulcer is a serious complication of diabetes. Compared with that of healthy people, the skin of patients with a diabetic ulcer is more easily damaged and difficult to heal. Without early intervention, the disease will become increasingly serious, often leading to amputation or even death. Most current treatment methods cannot achieve a good wound healing effect. Numerous studies have shown that a nanocomposite hydrogel serves as an ideal drug delivery method to promote the healing of a diabetic ulcer because of its better drug loading capacity and stability. Nanocomposite hydrogels can be loaded with one or more drugs for application to chronic ulcer wounds to promote rapid wound healing. Therefore, this paper reviews the latest progress of delivery systems based on nanocomposite hydrogels in promoting diabetic ulcer healing. Through a review of the recent literature, we put forward the shortcomings and improvement strategies of nanocomposite hydrogels in the treatment of diabetic ulcers.
糖尿病溃疡是糖尿病的一种严重并发症。与健康人相比，糖尿病溃疡患者的皮肤更容易受损且难以愈合。若不进行早期干预，病情会日益严重，常导致截肢甚至死亡。目前大多数治疗方法无法取得良好的伤口愈合效果。大量研究表明，纳米复合水凝胶因其具有更好的载药能力和稳定性，是促进糖尿病溃疡愈合的理想药物递送方法。纳米复合水凝胶可负载一种或多种药物用于慢性溃疡伤口，以促进伤口快速愈合。因此，本文综述了基于纳米复合水凝胶的递送系统在促进糖尿病溃疡愈合方面的最新进展。通过对近期文献的综述，我们提出了纳米复合水凝胶在治疗糖尿病溃疡方面的缺点及改进策略。
