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Interv Neuroradiol. 2007 Dec;13(4):329-33. doi: 10.1177/159101990701300403. Epub 2008 Feb 1.
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Angioplasty and stenting of the cervical carotid bifurcation under filter protection: a prospective study in a series of 53 patients.在滤器保护下对颈总动脉分叉处进行血管成形术和支架置入术：对53例患者的前瞻性研究。
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In vivo models of arterial thrombosis and thrombolysis.动脉血栓形成与溶栓的体内模型。
FASEB J. 1990 Oct;4(13):3087-98. doi: 10.1096/fasebj.4.13.2210155.

血管成形术和支架置入术中栓子保护系统的体内血栓形成性。

In vivo thrombogenicity of embolic protection systems for angioplasty and stenting.

作者信息

Raymond J, Guilbert F, Metcalfe A, Salazkin I, Gevry G, Leblanc P, Weill A, Roy D

机构信息

Radiology Department and Research Centre, CHUM-Notre-Dame Hospital, Montréal, Québec, CANADA - dr_jean_raymond @hotmail.com.

出版信息

Interv Neuroradiol. 2007 Dec;13(4):329-33. doi: 10.1177/159101990701300403. Epub 2008 Feb 1.

DOI:10.1177/159101990701300403
PMID:20566101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3329238/
Abstract

Despite the increasing use of embolic protection systems (EPS) for carotid stenting, their intrinsic in vivo thrombogenicity remains unknown. We studied three different types of EPS (n = 24) deployed in the carotid arteries of pigs in which pools of platelets and fibrinogen were labelled with (111)In and (125)I. The amount of clot deposition seen on photography was also scored using a qualitative scale. EPS made of fabric nets under normal flow conditions were 5-6 and 15-16 times more thrombogenic (for both platelet (P=.04) and fibrin (P=.007)) than Nitinol mesh nets. Clot deposition on Nitinol mesh nets was more abundant under flow arrest than under normal flow conditions (P=.018). EPS differ in intrinsic thrombogenicity, a characteristic of the material that could be investigated in pre-clinical studies designed to optimize devices.

摘要

尽管用于颈动脉支架置入术的栓子保护系统（EPS）的使用越来越多，但其内在的体内血栓形成性仍不清楚。我们研究了三种不同类型的EPS（n = 24），将其部署在猪的颈动脉中，其中血小板池和纤维蛋白原用（111）In和（125）I标记。摄影时观察到的凝块沉积量也使用定性量表进行评分。在正常血流条件下，由织物网制成的EPS的血栓形成性（对于血小板（P = .04）和纤维蛋白（P = .007））比镍钛诺网眼网高5至6倍和15至16倍。与正常血流条件相比，在血流停滞情况下镍钛诺网眼网上的凝块沉积更丰富（P = .018）。EPS的内在血栓形成性不同，这是一种材料特性，可在旨在优化器械的临床前研究中进行研究。