体离子通道对内耳毛细胞束自发性机械振荡的影响。

Effects of the somatic ion channels upon spontaneous mechanical oscillations in hair bundles of the inner ear.

机构信息

Department of Physics and Astronomy, University of California, Los Angeles, 475 Portola Plaza, Los Angeles, CA 90095, USA.

出版信息

Hear Res. 2010 Sep 1;268(1-2):163-71. doi: 10.1016/j.heares.2010.05.017. Epub 2010 Jun 1.

DOI:10.1016/j.heares.2010.05.017

PMID:20566385

Abstract

Decoupled hair bundles of the bullfrog (Lithobates catesbeianus) sacculus exhibit spontaneous oscillations in vitro. We examine the effect of the somatic electrical circuit upon active hair bundle motility. We found that innate bundle movements exhibit a complex profile with multiple periodicities. Inhibition of somatic ion channels using targeted neurotoxins and modified physiological solutions strongly affects the bundles' mechanical behavior, modifying the amplitude and the temporal characteristics of the oscillation profile.

摘要

牛蛙（Lithobates catesbeianus）球囊的分离毛束在体外表现出自发的振荡。我们研究了体腔电回路对活性毛束运动的影响。我们发现，固有束运动表现出具有多个周期性的复杂形态。使用靶向神经毒素和改良生理溶液抑制体细胞离子通道强烈影响束的机械行为，改变了振荡形态的幅度和时间特征。