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环磷酸腺苷结合蛋白：在去卵巢诱导的Sprague-Dawley雌性大鼠激素依赖性乳腺肿瘤消退中的作用

Cyclic adenosine 3',5'-monophosphate-binding protein: role in ovariectomy-induced regression of a hormone-dependent mammary tumor in Sprague-Dawley female rats.

作者信息

Cho-Chung Y S, Bodwin J S, Clair T

出版信息

J Natl Cancer Inst. 1978 May;60(5):1175-8. doi: 10.1093/jnci/60.5.1175.

DOI:10.1093/jnci/60.5.1175
PMID:205664
Abstract

Cyclic AMP- and estrogen-binding activities were present in 7,12-dimethylbenz[a]anthracene-induced mammary carcinomas in Sprague-Dawley female rats. Soon after ovariectomy of the host, cyclic AMP binding markedly increased and estrogen binding decreased in regressing tumors. These changes were reversed when tumor growth was resumed following the injection of estradiol-17beta. The data suggested the possible involvement of cyclic AMP binding in the growth control of a hormone-dependent mammary tumor.

摘要

环磷酸腺苷（cAMP）结合活性和雌激素结合活性存在于用7,12-二甲基苯并[a]蒽诱导的斯普拉格-道利雌性大鼠乳腺癌中。宿主卵巢切除后不久，正在消退的肿瘤中cAMP结合显著增加，而雌激素结合减少。注射17β-雌二醇后肿瘤生长恢复时，这些变化发生逆转。数据表明cAMP结合可能参与激素依赖性乳腺肿瘤的生长调控。

相似文献

1
Cyclic adenosine 3',5'-monophosphate-binding protein: role in ovariectomy-induced regression of a hormone-dependent mammary tumor in Sprague-Dawley female rats.环磷酸腺苷结合蛋白：在去卵巢诱导的Sprague-Dawley雌性大鼠激素依赖性乳腺肿瘤消退中的作用
J Natl Cancer Inst. 1978 May;60(5):1175-8. doi: 10.1093/jnci/60.5.1175.
2
Inverse relation between estrogen receptors and cyclic adenosine 3':5'-monophosphate-binding proteins in hormone-dependent mammary tumor regression due to dibutyryl cyclic adenosine 3':5'-monophosphate treatment or ovariectomy.在因二丁酰环磷腺苷治疗或卵巢切除导致的激素依赖性乳腺肿瘤消退过程中，雌激素受体与环磷腺苷3':5'-单磷酸结合蛋白之间的负相关关系。
Cancer Res. 1978 Oct;38(10):3410-3.
3
Cyclic AMP-binding proteins: inverse relationship with estrogen-receptors in hormone-dependent mammary tumor regression.环磷酸腺苷结合蛋白：与激素依赖性乳腺肿瘤消退中雌激素受体的负相关关系。
Eur J Biochem. 1978 May;86(1):51-60. doi: 10.1111/j.1432-1033.1978.tb12283.x.
4
Antagonistic action between cyclic adenosine 3':5'-monophosphate and estrogen in rat mammary tumor growth control.环磷酸腺苷与雌激素在大鼠乳腺肿瘤生长控制中的拮抗作用。
Cancer Res. 1978 Nov;38(11 Pt 2):4071-5.
5
Regression of hormone-dependent mammary tumors in Sprague-Dawley rats as a result of tamoxifen or pharmacologic doses of 17 beta-estradiol: cyclic adenosine 3',5'-monophosphate-mediated events.他莫昔芬或药理剂量的17β-雌二醇导致斯普拉格-道利大鼠激素依赖性乳腺肿瘤消退：环磷酸腺苷介导的事件
J Natl Cancer Inst. 1981 Feb;66(2):321-6.
6
Relationship of adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate to growth of dimethylbenz(a)anthracene-induced mammary tumors in rats.3',5'-环磷酸腺苷和3',5'-环磷酸鸟苷与二甲基苯并(a)蒽诱导的大鼠乳腺肿瘤生长的关系。
J Natl Cancer Inst. 1976 Mar;56(3):659-61. doi: 10.1093/jnci/56.3.659.
7
Levels of cyclic nucleotides in autotransplanted 7, 12-dimethylbenz[a]anthracene-induced rat mammary tumors during their growth and regression.自体移植的7,12-二甲基苯并[a]蒽诱导的大鼠乳腺肿瘤在生长和消退过程中环状核苷酸的水平。
J Natl Cancer Inst. 1980 Nov;65(5):1029-32.
8
Dibutyryl cyclic AMP mimics ovariectomy: nuclear protein phosphorylation in mammary tumor regression.二丁酰环磷腺苷模仿卵巢切除术：乳腺肿瘤消退过程中的核蛋白磷酸化
Science. 1977 Jul 15;197(4300):272-5. doi: 10.1126/science.195337.
9
Cyclic AMP-binding protein and estrogen receptor: antagonism during nuclear translocation in a hormone-dependent mammary tumor.环磷酸腺苷结合蛋白与雌激素受体：在激素依赖性乳腺肿瘤核转位过程中的拮抗作用
Biochem Biophys Res Commun. 1981 Dec 31;103(4):1349-55. doi: 10.1016/0006-291x(81)90271-0.
10
Relationship of hormone dependency to estrogen receptor and adenosine 3',5'-cyclic monophosphate-binding proteins in rat mammary tumors.大鼠乳腺肿瘤中激素依赖性与雌激素受体及环磷酸腺苷结合蛋白的关系。
J Natl Cancer Inst. 1980 Feb;64(2):395-8. doi: 10.1093/jnci/64.2.395.

引用本文的文献

1
3,4-bis(3'-hydroxyphenyl)hexane--a new mammary tumor-inhibiting compound. Studies on the mechanism of action on the DMBA-induced, hormone-dependent mammary tumor of the rat.3,4-双（3'-羟基苯基）己烷——一种新型乳腺肿瘤抑制化合物。对大鼠二甲基苯并蒽诱导的激素依赖性乳腺肿瘤作用机制的研究。
J Cancer Res Clin Oncol. 1982;103(3):241-54. doi: 10.1007/BF00409700.