Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Vasco de Quiroga 15, Seccion XVI, Tlalpan, 14000 Mexico DF, Mexico.
Eur J Endocrinol. 2010 Sep;163(3):469-77. doi: 10.1530/EJE-10-0454. Epub 2010 Jun 21.
Fibroblast growth factor 21 (FGF21) levels have been linked with beneficial effects on glucose and lipid metabolism in animals. It is elevated in humans with the metabolic syndrome. This study investigates independent factors associated with serum FGF21 levels.
Cross-sectional study done in healthy blue-collar workers.
A medical history was taken, and FGF21 (measured using an ELISA commercial kit), glucose, uric acid, plasma lipids, total/high-molecular weight (HMW) adiponectin, and retinal-binding protein 4 (RBP4) were measured in 210 individuals with (n=81) and without (n=129) metabolic syndrome.
The median of serum FGF21 levels were higher in subjects with metabolic syndrome (339.5 vs 276.4 ng/l, P=0.01). Serum FGF21 levels correlated positively with body mass index (BMI; r=0.23, P=0.001) and age (r=0.17, P=0.01). After adjusting for age and BMI, a significant positive correlation persisted for fasting glucose, uric acid, and physical activity in both males (r=0.21, r=0.11, and r=0.19, all P<0.05) and females (r=0.20, r=0.19, and r=0.14, all P<0.05). In addition, FGF21 also correlates negatively with RBP4 (r=-0.27, P=0.02), total (r=-0.26, P=0.03), and HMW adiponectin (r=-0.30, P=0.01) in women. A multiple linear regression model analysis identified that BMI (standardized beta (SB)=0.247; P=0.008), glucose (SB=0.226; P=0.003), uric acid (SB=0.191; P=0.04), and physical activity (SB=0.223; P=0.004) are independent factors influencing serum FGF21 levels (F=10.05, r(2)=0.19, P<0.001). In addition, fasting hyperglycemia > or =100 mg/dl, excess body weight with BMI > or =25 kg/m(2), and uric acid > or =5.5 mg/dl predicted higher serum FGF21 levels.
Serum FGF21 levels are influenced by BMI, fasting glycemia, uric acid, and physical activity.
成纤维细胞生长因子 21（FGF21）水平与动物的葡萄糖和脂质代谢有益影响有关。它在患有代谢综合征的人类中升高。本研究调查与血清 FGF21 水平相关的独立因素。
在健康蓝领工人中进行的横断面研究。
对 210 名患有（n=81）和不患有（n=129）代谢综合征的个体进行了病史记录，并使用 ELISA 商业试剂盒测量了 FGF21（测量）、血糖、尿酸、血浆脂质、总/高分子量（HMW）脂联素和视网膜结合蛋白 4（RBP4）。
代谢综合征患者的血清 FGF21 水平中位数较高（339.5 与 276.4 ng/l，P=0.01）。血清 FGF21 水平与体重指数（BMI；r=0.23，P=0.001）和年龄（r=0.17，P=0.01）呈正相关。调整年龄和 BMI 后，男性（r=0.21，r=0.11，r=0.19，均 P<0.05）和女性（r=0.20，r=0.19，r=0.14，均 P<0.05）的空腹血糖、尿酸和体力活动与 FGF21 仍呈显著正相关。此外，FGF21 还与女性的 RBP4（r=-0.27，P=0.02）、总（r=-0.26，P=0.03）和 HMW 脂联素（r=-0.30，P=0.01）呈负相关。多元线性回归模型分析表明，BMI（标准化β（SB）=0.247；P=0.008）、葡萄糖（SB=0.226；P=0.003）、尿酸（SB=0.191；P=0.04）和体力活动（SB=0.223；P=0.004）是影响血清 FGF21 水平的独立因素（F=10.05，r(2)=0.19，P<0.001）。此外，空腹高血糖>或=100mg/dl、BMI>或=25kg/m(2)的超重和尿酸>或=5.5mg/dl 预测血清 FGF21 水平较高。
血清 FGF21 水平受 BMI、空腹血糖、尿酸和体力活动影响。
