成纤维细胞生长因子21在子宫内膜癌及子宫体其他病变中的诊断作用

The Diagnostic Role of FGF 21 in Endometrial Cancer and Other Pathologies of the Uterine Corpus.

作者信息

Jagodzińska Anna, Chudecka-Głaz Anita, Michalczyk Kaja, Pius-Sadowska Ewa, Wieder-Huszla Sylwia, Jurczak Anna, Machaliński Bogusław

机构信息

Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, 70-204 Szczecin, Poland.

Department of General Pathology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.

出版信息

Diagnostics (Basel). 2023 Jan 22;13(3):399. doi: 10.3390/diagnostics13030399.

DOI:10.3390/diagnostics13030399

PMID:36766504

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9914808/

Abstract

Endometrial cancer is becoming an increasing problem. Taking into account its pathomechanisms, we aimed to investigate whether FGF 21, an important metabolism regulator, could be used as a biomarker for endometrial cancer. The study included 233 patients who were classified into five subgroups depending on the result of the histological examination: endometrial carcinomas, sarcomas, endometrial polyps, fibroids, and normal endometrium. Statistically significantly higher FGF 21 levels were found in patients diagnosed with malignant lesions ( < 0.001). FGF 21 concentration correlated with the degree of cellular differentiation ( = 0.020) and the presence of lymph node metastases ( = 0.009). The diagnostic performance characteristics of FGF 21 as an EC diagnostic marker demonstrated an AUC of 0.677. Of all of the assessed biomarkers, FGF 21 had the highest specificity (90%), yet limited sensitivity (41%). Additionally, HE4 and CA 125 were confirmed to have roles as EC biomarkers, with a higher accuracy for HE4 (79% vs. 72%).

摘要

子宫内膜癌正成为一个日益严重的问题。考虑到其发病机制，我们旨在研究重要的代谢调节因子FGF 21是否可作为子宫内膜癌的生物标志物。该研究纳入了233例患者，根据组织学检查结果将其分为五个亚组：子宫内膜癌、肉瘤、子宫内膜息肉、子宫肌瘤和正常子宫内膜。在诊断为恶性病变的患者中发现FGF 21水平在统计学上显著更高（<0.001）。FGF 21浓度与细胞分化程度（=0.020）和淋巴结转移情况（=0.009）相关。FGF 21作为子宫内膜癌诊断标志物的诊断性能特征显示曲线下面积（AUC）为0.677。在所有评估的生物标志物中，FGF 21具有最高的特异性（90%），但敏感性有限（41%）。此外，HE4和CA 125被证实可作为子宫内膜癌生物标志物，HE4的准确性更高（79%对72%）。