First Department of Pediatrics, Semmelweis University, Budapest, Budapest, Hungary.
Hypertension. 2010 Aug;56(2):217-24. doi: 10.1161/HYPERTENSIONAHA.110.152686. Epub 2010 Jun 21.
Carotid-femoral pulse wave velocity is an established method for characterizing aortic stiffness, an individual predictor of cardiovascular mortality in adults. Normal pulse wave velocity values for the pediatric population derived from a large data collection have yet to be available. The aim of this study was to create a reference database and to characterize the factors determining pulse wave velocity in children and teenagers. Carotid-femoral pulse wave velocity was measured by applanation tonometry. Reference tables from pulse wave velocities obtained in 1008 healthy subjects (aged between 6 and 20 years; 495 males) were generated using a maximum-likelihood curve-fitting technique for calculating SD scores in accordance with the skewed distribution of the raw data. Effects of sex, age, height, weight, blood pressure, and heart rate on pulse wave velocity were assessed. Sex-specific reference tables and curves for age and height are presented. Pulse wave velocity correlated positively (P<0.001) with age, height, weight, and blood pressure while correlating negatively with heart rate. After multiple regression analysis, age, height, and blood pressure remained major predictors of pulse wave velocity. This study, involving >1000 children, is the first to provide reference values for pulse wave velocity in children and teenagers, thereby constituting a suitable tool for longitudinal clinical studies assessing subgroups of children who are at long-term risk of cardiovascular disease.
颈动脉-股动脉脉搏波速度是一种用于描述主动脉僵硬度的方法，主动脉僵硬度是成年人心血管死亡率的独立预测因子。目前还没有从大量数据中得出的儿科人群正常脉搏波速度值。本研究旨在创建一个参考数据库，并描述决定儿童和青少年脉搏波速度的因素。通过平板压力测量法测量颈动脉-股动脉脉搏波速度。使用最大似然曲线拟合技术，根据原始数据的偏态分布，为 1008 名健康受试者（年龄在 6 至 20 岁之间；495 名男性）获得的脉搏波速度生成参考表，以计算 SD 分数。评估性别、年龄、身高、体重、血压和心率对脉搏波速度的影响。呈现了性别特异性的年龄和身高参考表和曲线。脉搏波速度与年龄、身高、体重和血压呈正相关（P<0.001），与心率呈负相关。经过多元回归分析，年龄、身高和血压仍然是脉搏波速度的主要预测因子。这项涉及 1000 多名儿童的研究首次提供了儿童和青少年脉搏波速度的参考值，从而为评估长期患心血管疾病风险的儿童亚组的纵向临床研究提供了合适的工具。
