脆性 X 综合征儿童和青少年的自闭症谱系障碍：综合征内差异和与年龄相关的变化。
Autism spectrum disorder in children and adolescents with fragile X syndrome: within-syndrome differences and age-related changes.
机构信息
University of Wisconsin, Waisman Center, Madison, WI 53705, USA.
出版信息
Am J Intellect Dev Disabil. 2010 Jul;115(4):307-26. doi: 10.1352/1944-7558-115.4.307.
Abstract
The Autism Diagnostic Interview-Revised (ADI-R) was used to examine diagnostic profiles and age-related changes in autism symptoms for a group of verbal children and adolescents who had fragile X syndrome, with and without autism. After controlling for nonverbal IQ, we found statistically significant between-group differences for lifetime and current autism symptoms for the Communication and Restricted Interests/Repetitive Behaviors domains, but not the Reciprocal Social Interaction domain. Effect sizes for differences in Reciprocal Social Interaction also were smaller than effect sizes for the other domains, with one exception. Overall, severity of autism symptoms improved with age for all participants, with the least improvement noted for Restricted Interests and Repetitive Behaviors. FMRP did not account for unique variance in autism symptoms over and above nonverbal IQ.
摘要
使用孤独症诊断访谈修订版（ADI-R）来检查一组有脆性 X 综合征的语言儿童和青少年的诊断特征和与年龄相关的孤独症症状变化，包括有孤独症和没有孤独症的个体。在控制非言语智商后，我们发现沟通和受限兴趣/重复行为领域的终生和当前孤独症症状存在统计学上的显著组间差异，但互惠社会互动领域没有。互惠社会互动差异的效应大小也小于其他领域的效应大小，但有一个例外。总的来说，所有参与者的孤独症症状严重程度都随年龄增长而改善，受限兴趣和重复行为的改善最小。FMRP 不能解释孤独症症状的独特变化，超出非言语智商的影响。
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