DermSurgery Associates, Houston, Texas.
Semin Plast Surg. 2007 Aug;21(3):167-74. doi: 10.1055/s-2007-991185.
Traditional medical treatments for acne vulgaris include a variety of topical and oral medications. The combination of poor compliance, lack of durable remission, and potential side effects are common drawbacks to these treatments. The use of lasers and light devices has increased dramatically in recent years due to the overall ease of treatment, predictable clinical efficacy, and minimal adverse effects. A variety of light and laser devices has been used for the treatment of acne, including the potassium titanyl phosphate (KTP) laser, the 585- and 595-nm pulsed dye lasers, the 1450-nm diode laser, radiofrequency devices, intense pulsed light sources, low-intensity light treatment, and photodynamic therapy using 5-aminolevulinic acid and indocyanine green. These devices are thought to target underlying pathogenic factors such as Propionibacterium acnes colonization, increased sebaceous gland activity, and the cutaneous inflammatory response. Lasers in particular also have a central role in the management of acne scarring, which tends to be refractory to medical therapies. Fractional photothermolysis, the 1450-nm diode laser, and pulsed dye lasers have been used in the nonablative treatment of acne scars with significant success. In this article, we review the current status of light- and laser-based treatment of acne and related conditions and briefly review the use of lasers for the treatment of acne scarring.
传统的痤疮治疗方法包括各种局部和口服药物。这些治疗方法的常见缺点是患者的依从性差、缓解效果不持久以及潜在的副作用。近年来,由于治疗的总体便利性、可预测的临床疗效和最小的不良反应,激光和光设备的使用有了显著增加。已经有多种光和激光设备被用于治疗痤疮,包括钛钾磷酸盐(KTP)激光、585nm 和 595nm 脉冲染料激光、1450nm 二极管激光、射频设备、强脉冲光光源、低强度光治疗以及使用 5-氨基酮戊酸和吲哚菁绿的光动力疗法。这些设备被认为可以针对痤疮发病的潜在致病因素,如痤疮丙酸杆菌定植、皮脂腺活动增加和皮肤炎症反应。激光在痤疮瘢痕的管理中也具有重要作用,因为瘢痕往往对药物治疗有抗性。分光斑光热分解、1450nm 二极管激光和脉冲染料激光已被成功地用于非消融性痤疮瘢痕治疗。本文综述了光和激光治疗痤疮及相关疾病的现状,并简要回顾了激光治疗痤疮瘢痕的应用。