Chu Gong-Yau, Huang Chieh-Chen, Shih Nai-Hua, Hsu Chung-Hua, Wu Ching-Ying
Institute of Traditional Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei 30010, Taiwan.
Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei 30010, Taiwan.
J Clin Med. 2023 Jul 5;12(13):4500. doi: 10.3390/jcm12134500.
Acne vulgaris remains the leading dermatological condition. The efficacy of laser treatment has been supported by many clinical studies, but studies investigating its multidimensional action are lacking.
To comprehensively investigate the efficacy of 1450-nm diode laser treatment in patients with inflammatory acne and provide objective and subjective data for doctors in clinical practice.
This retrospective study included patients with inflammatory acne lesions who underwent three courses of 1450-nm diode laser treatment between October 2019 and August 2020. Facial surface analysis was performed via objective computer assessments using the Canfield VISIA imaging system. Post-treatment subjective assessments were retrieved and analyzed using the clinical global impression-improvement index (CGI-I) and patient global impression of improvement scales (PGI-I).
The final analysis included 20 patients. The changes in the porphyrin VISIA system scores demonstrated significant improvement, with median scores being 35.83, 48.83, and 54.83, respectively. The changes in the red area VISIA scores also showed improvement, with the median scores being 48, 50.33, and 58.83, respectively. The average CGI-I scale scores were 2.2 ± 1.01, 1.70 ± 0.80, and 1.50 ± 0.76, respectively ( = 0.001), and the average PGI-I scale scores were 3.10 ± 0.85, 3.10 ± 0.97, and 3.05 ± 0.95, respectively ( = 0.727), with no significant changes observed in sebum production.
The present study is the first to provide objective and subjective evidence proving that the 1450-nm diode laser can reduce inflammatory acne lesions.
寻常痤疮仍然是主要的皮肤病。许多临床研究已证实激光治疗的疗效，但缺乏对其多维作用的研究。
全面研究1450纳米二极管激光治疗炎性痤疮患者的疗效，并为临床医生提供客观和主观数据。
这项回顾性研究纳入了在2019年10月至2020年8月期间接受三个疗程1450纳米二极管激光治疗的炎性痤疮患者。使用Canfield VISIA成像系统通过客观计算机评估进行面部表面分析。使用临床整体印象改善指数（CGI-I）和患者整体改善印象量表（PGI-I）检索并分析治疗后的主观评估。
最终分析纳入了20名患者。卟啉VISIA系统评分的变化显示出显著改善，中位数分别为35.83、48.83和54.83。红色区域VISIA评分的变化也显示出改善，中位数分别为48、50.33和58.83。CGI-I量表的平均评分分别为2.2±1.01、1.70±0.80和1.50±0.76（P = 0.001），PGI-I量表的平均评分分别为3.10±0.85、3.10±0.97和3.05±0.95（P = 0.727），皮脂分泌未见显著变化。
本研究首次提供了客观和主观证据，证明1450纳米二极管激光可减少炎性痤疮皮损。
