Department of Clinical Laboratory Science, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-kogushi, Ube, Yamaguchi 755-8505, Japan.
J Infect Chemother. 2010 Dec;16(6):446-8. doi: 10.1007/s10156-010-0081-5. Epub 2010 Jun 22.
Bartonella henselae, a small fastidious Gram-negative bacillus, is the causative agent of cat-scratch disease (CSD). Because of difficulty in isolating the organism, there has been no report on its antibiotic susceptibility in Japan. We determined the minimal inhibitory concentrations (MICs) of eight antimicrobial agents against 32 isolates of B. henselae (31 from cats and one from a human in Japan) by the Etest method. MICs of all 32 isolates were <0.016 μg/ml for minocycline and ranged from ≤0.016 to 0.064 μg/ml for erythromycin, clarithromycin, azithromycin, ceftriaxone, and amoxicillin. MICs ranges of ciprofloxacin and gentamicin were from 0.064 to 0.25 μg/ml and from 0.5 to 3 μg/ml, respectively. All isolated strains showed high susceptibility to minocycline and macrolides antibiotics, which are currently used in the primary treatment of CSD in Japan. Although in vitro result of B. henselae susceptibility testing may not necessarily correlate with clinical response, these data are relevant in the choice of drugs for CSD treatment.
汉赛巴尔通体（Bartonella henselae）是一种体积微小、挑剔的革兰氏阴性杆菌，是猫抓病（CSD）的病原体。由于该病原体难以分离培养，日本尚未有关于其药敏性的报告。我们采用 Etest 法测定了 32 株汉赛巴尔通体（31 株来自猫，1 株来自日本的人类）对 8 种抗菌药物的最小抑菌浓度（MIC）。所有 32 株分离株对米诺环素的 MIC 均<0.016 μg/ml，对红霉素、克拉霉素、阿奇霉素、头孢曲松和阿莫西林的 MIC 范围为≤0.016-0.064 μg/ml。环丙沙星和庆大霉素的 MIC 范围分别为 0.064-0.25 μg/ml 和 0.5-3 μg/ml。所有分离株均对米诺环素和大环内酯类抗生素高度敏感，这两种抗生素目前被用于日本 CSD 的一线治疗。虽然汉赛巴尔通体体外药敏试验结果不一定与临床疗效相关，但这些数据对于 CSD 治疗药物的选择具有重要意义。
