Zhou Fang, Qin Weidong, Wang Yuzhen, Li Weihui, Liang Shoupei, Yao Wu, Wu Yiming
Department of Occupational Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Wei Sheng Yan Jiu. 2010 May;39(3):279-82.
To explore the effect of heat shock protein 70(HSP70) gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker (CWP).
100 workers whose sternites were assessed 0+ were chosen as the case group and 100 workers as the control. HSP70 genotypes were analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
There were significantly differences in HSP70-1 b2/b2 genotype (chi2 = 8.26, P < 0.05) between the case group and the control ,the risks of CWP in the individuals with b2/b2 genotype were 2.36 times than those with b1/b1 genotype. The polymorphism of HSP70-2 and HSP70-hom had no statistics significance in the difference of the two groups.
The results suggested that the individual with HSP70-1 b2/b2 genotype may be a predisposing genotype to CWP and the individuals with the genotype could have weaker adaptability than the others.
探讨热休克蛋白70（HSP70）基因多态性对煤工尘肺（CWP）遗传易感性的影响。
选取100名胸片诊断为0+的工人作为病例组，另选100名工人作为对照组。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术分析HSP70基因分型。
病例组与对照组之间HSP70-1 b2/b2基因型存在显著差异（χ2 = 8.26，P < 0.05），b2/b2基因型个体患CWP的风险是b1/b1基因型个体的2.36倍。HSP70-2和HSP70-hom的多态性在两组差异中无统计学意义。
结果表明，HSP70-1 b2/b2基因型个体可能是CWP的易感基因型，该基因型个体的适应性可能比其他个体弱。
