Stangel-Wójcikiewicz Klaudia, Majka Marcin, Basta Antoni, Stec Małgorzata, Pabian Wojciech, Piwowar Monika, Chancellor Michael B
Department of Gynecology and Oncology, Collegium Medium Jagiellonian University of Kraków.
Ginekol Pol. 2010 May;81(5):378-81.
The past few years brought high development in obtaining and culturing autologous adult stem cells. In this paper we review publications of experimental investigations and clinical trials of the muscle-derived cells and the application in the treatment of stress urinary incontinence among women. Mesenchymal stem cells (MSCs) can be obtained from bone marrow but it is associated with a painful biopsy procedure. Collection of muscle-derived stem cells (MDSCs) is less harmful because the skeletal muscle biopsy is performed with a small caliber needle in local anesthesia. The stem-based therapy could be the next step in the treatment of urinary incontinence. There are still many elements of therapy such as effectiveness or long-term side effects which need to be researched.
在过去几年中，自体成体干细胞的获取和培养取得了高度发展。在本文中，我们回顾了关于肌肉来源细胞的实验研究和临床试验的出版物，以及其在治疗女性压力性尿失禁中的应用。间充质干细胞（MSCs）可从骨髓中获取，但这与痛苦的活检程序相关。肌肉来源干细胞（MDSCs）的采集危害较小，因为骨骼肌活检是在局部麻醉下用小口径针头进行的。基于干细胞的疗法可能是治疗尿失禁的下一步。治疗中仍有许多要素，如有效性或长期副作用，需要进行研究。
