Januszek Grzegorz, Niemczyk Kazimierz, Górnicka Barbara, Gotlib Tomasz
Katedra i Klinika Otolaryngologii SP CSK AM w Warszawie.
Otolaryngol Pol. 2010 Mar-Apr;64(2):88-92. doi: 10.1016/S0030-6657(10)70041-X.
Chondromyxoid fibroma (CMF) is a rare benign tumor, typically occurring in the metaphysis of long bones. Involvement of craniofacial bones is extremely unusual. The histologic diagnosis of this tumor is difficult because of its similarities to chondrosarcoma. Preferably, chondromyxoid fibroma is treated by complete local excision. Recurrences, or soft tissue implants, may follow incomplete curettage.
Presentation of the case of 51-year-old woman who presented with a CFM of the nasal septum with extension into the maxillary and sphenoid sinuses. In addition, a literature review of the clinical and histologic features, as well as recommended modalities of treatment, are presented.
Analysis of clinical records of patient treated of CMF in Department of Otolaryngology Warsaw Medical Univercity. Radiologic imaging showed a soft tissue lesion invading the adjacent bony structures. The initial microscopic examination of a segment of the tumor gives no diagnose. The tumor was excised. Postoperative microscopical examination of the tumor revealed the typical pathologic features of CMF. Patient was free of disease at 12-month follow-up. After it signs of recurrence appeared. Reoperation was performed.
Although surgery is a base of treatment, radiotherapy should also be discussed. Surgical excision must be complete. Radiotherapy should to be reserved for the cases that are surgically difficult to reach. Because of the similarities between CMF and chondrosarcoma, great care must be taken in the assessment of the biopsy.
软骨黏液样纤维瘤（CMF）是一种罕见的良性肿瘤，通常发生于长骨的干骺端。累及颅面骨极为罕见。由于该肿瘤与软骨肉瘤相似，其组织学诊断较为困难。软骨黏液样纤维瘤最好通过局部完整切除进行治疗。刮除不完全可能导致复发或软组织植入。
介绍一名51岁女性患者的病例，该患者患有鼻中隔软骨黏液样纤维瘤，并累及上颌窦和蝶窦。此外，还对其临床和组织学特征以及推荐的治疗方式进行了文献综述。
分析华沙医科大学耳鼻喉科治疗的软骨黏液样纤维瘤患者的临床记录。放射影像学显示一个软组织病变侵犯了相邻的骨结构。对肿瘤的一部分进行初步显微镜检查未得出诊断结果。肿瘤被切除。术后对肿瘤进行显微镜检查显示出软骨黏液样纤维瘤的典型病理特征。患者在12个月随访时无疾病迹象。之后出现了复发迹象，进行了再次手术。
尽管手术是治疗的基础，但也应考虑放疗。手术切除必须彻底。放疗应保留用于手术难以触及的病例。由于软骨黏液样纤维瘤与软骨肉瘤相似，在活检评估时必须格外小心。
