Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht.
Int Clin Psychopharmacol. 2010 Jul;25(4):232-40. doi: 10.1097/yic.0b013e328338c4f0.
Obsessive-compulsive disorder (OCD) is associated with deficits in inhibition mechanisms. This is reflected in reports showing impaired sensorimotor and sensory gating in OCD patients, as measured with prepulse inhibition (PPI) of the startle reflex and P50 suppression paradigms. However, most of the patients in these studies used medication and the results were not controlled for menstrual cycle phase in women. In this study PPI and P50 suppression were tested in 25 medication-free OCD patients and 25 healthy controls, using auditory stimuli and controlling for menstrual cycle effects. Subgroups were established, based on clinical variables (e.g. 'washers' and 'checkers'). No impairments in PPI or P50 suppression were found in the OCD group when compared with healthy controls. However, a subgroup of OCD patients ('checkers', n=12) showed increased P50 suppression. It was concluded that sensorimotor and sensory gating is not impaired in drug-free OCD patients, taking into account the menstrual cycle effects in women. These results do not support hypotheses linking deficits in these inhibition paradigms and the pathogenesis of OCD. The finding of an increased P50 suppression in the subgroup of 'checkers' deserves further investigation and underlines the value of studying subgroups of OCD.
强迫症（OCD）与抑制机制缺陷有关。这反映在报告中，表明 OCD 患者的感觉运动和感觉门控受损，这可以通过惊吓反射的预脉冲抑制（PPI）和 P50 抑制范式来测量。然而，这些研究中的大多数患者都在使用药物，并且没有针对女性的月经周期阶段进行结果控制。在这项研究中，使用听觉刺激并控制月经周期的影响，在 25 名未服用药物的 OCD 患者和 25 名健康对照者中测试了 PPI 和 P50 抑制。根据临床变量（例如“洗衣机”和“检查器”）建立了亚组。与健康对照组相比，OCD 组在 PPI 或 P50 抑制方面没有发现任何损伤。然而，OCD 患者的一个亚组（“检查器”，n=12）表现出 P50 抑制增加。结论是，考虑到女性的月经周期影响，在未服用药物的 OCD 患者中，感觉运动和感觉门控没有受损。这些结果不支持将这些抑制范式缺陷与 OCD 发病机制联系起来的假设。在“检查器”亚组中发现的 P50 抑制增加值得进一步研究，并强调了研究 OCD 亚组的价值。
