Rumessen J J, Vanderwinden J-M, Horn T
Department of Gastroenterology F, Gentofte Hospital, Hellerup, Denmark.
Ultrastruct Pathol. 2010 Oct;34(5):279-87. doi: 10.3109/01913121003770701.
Interstitial cells of Cajal (ICC) are key regulatory cells in the gut. In the colon of patients with severe ulcerative colitis (UC), myenteric ICC had myoid ultrastructural features and were in close contact with nerve terminals. In all patients as opposed to controls, some ICC profiles showed degenerative changes, such as lipid droplets and irregular vacuoles. Nerve terminals often appeared swollen and empty. Glial cells, muscle cells, and fibroblast-like cells (FLC) showed no alterations. FLC enclosed macrophages (MLC), which were in close contact with naked axon terminals. The organization and cytological changes may be of pathophysiological significance in patients with UC.
Cajal间质细胞（ICC）是肠道中的关键调节细胞。在重症溃疡性结肠炎（UC）患者的结肠中，肌间ICC具有肌样超微结构特征，并与神经末梢紧密接触。与对照组相比，所有患者的一些ICC形态均显示出退行性变化，如脂滴和不规则空泡。神经末梢常出现肿胀和空泡化。神经胶质细胞、肌肉细胞和成纤维细胞样细胞（FLC）未显示改变。FLC包裹着巨噬细胞（MLC），MLC与裸露的轴突末梢紧密接触。这些组织结构和细胞学变化可能对UC患者具有病理生理学意义。
