Faculty of Medicine, Institute Clinic of Gynecology, Obstetrics and Neonatology, University of Barcelona, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS): Barcelona, Spain.
Gynecol Endocrinol. 2010 Oct;26(10):736-42. doi: 10.3109/09513590.2010.481025.
To investigate glyco-lipidic metabolism and androgenic profile in a cohort of women with polycystic ovary syndrome (PCOS) divided according to Rotterdam phenotypes and body mass index (BMI).
A prospective case-control study.
Gynecology department in a teaching hospital. Patients. A total of 223 PCOS women and 25 healthy control women were studied.
Patients and controls were subdivided into three groups according to their BMI: normal weight (18.5 ≤ [BMI] ≤24.9 kg/m(2)), overweight (25.0 ≤ BMI ≤29.9 kg/m(2)), or obese (BMI ≥30.0 kg/m(2)) and according to Rotterdam criteria of PCOS. Main outcome measures. Pituitary-gonadal axis assessment including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, PRL, testosterone, androstenedione, DHEA-S, 17-hydroxyprogesterone and inhibin B. Metabolic parameters included cholesterol (Chol), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG) and apolipoproteins (APO) AII and B as well as serum fasting insulin, glucose and HOMA-IR.
Serum fasting insulin, glucose, HOMA-IR, TG and HDL were significantly higher in women with PCOS compared to controls. Additionally, serum levels of Chol, LDL and TG were significantly higher and HDL levels were significantly lower in obese PCOS women compared with overweight/normal PCOS irrespective of Rotterdam phenotypes. Free testosterone index but not androstenedione or total testosterone significantly correlated with TG, HDL and APO B. No significant correlations were detected between gonadotropins, inhibin B or estradiol with metabolic parameters studied.
Obesity but not overweight in PCOS is associated with dyslipidemia. Hyperandrogenic women showed the most atherogenic lipid profiles.
根据 Rotterdam 标准和体重指数（BMI）将多囊卵巢综合征（PCOS）患者分为不同亚组，研究其糖脂代谢和雄激素特征。
前瞻性病例对照研究。
教学医院的妇科。
共纳入 223 例 PCOS 患者和 25 例健康对照者。
根据 BMI 将患者和对照者分为三组：正常体重组（18.5≤BMI≤24.9kg/m²）、超重组（25.0≤BMI≤29.9kg/m²）或肥胖组（BMI≥30.0kg/m²），并根据 Rotterdam 标准对 PCOS 患者进行分组。
垂体-性腺轴评估包括卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇、泌乳素（PRL）、睾酮、雄烯二酮、硫酸脱氢表雄酮（DHEA-S）、17-羟孕酮和抑制素 B。代谢参数包括胆固醇（Chol）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、甘油三酯（TG）、载脂蛋白（APO）AII 和 B 以及血清空腹胰岛素、血糖和胰岛素抵抗指数（HOMA-IR）。
与对照组相比，PCOS 患者的血清空腹胰岛素、血糖、HOMA-IR、TG 和 HDL 水平显著升高。此外，与超重/正常体重的 PCOS 妇女相比，肥胖的 PCOS 妇女的血清 Chol、LDL 和 TG 水平显著升高，HDL 水平显著降低，无论 Rotterdam 标准如何。游离睾酮指数而非雄烯二酮或总睾酮与 TG、HDL 和 APO B 显著相关。未发现促性腺激素、抑制素 B 或雌二醇与所研究的代谢参数之间存在显著相关性。
肥胖而非超重的 PCOS 与血脂异常有关。高雄激素血症妇女表现出最具动脉粥样硬化倾向的血脂谱。
