非肥胖型多囊卵巢综合征患者平均血小板体积与雄激素及胰岛素抵抗的相关性
Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome.
作者信息
Dogan Bercem Aycicek, Arduc Ayse, Tuna Mazhar Muslum, Karakılıc Ersen, Dagdelen Iffet, Tutuncu Yasemin, Berker Dilek, Guler Serdar
机构信息
Ankara Numune Training and Research Hospital, Endocrinology and Metabolism Disease, Ankara, Turkey.
National Institute of Diabetes and Digestive and Kidney Diseases, Diabetes-Endocrine and Obesity Branch, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
Int J Endocrinol Metab. 2014 Oct 1;12(4):e18642. doi: 10.5812/ijem.18642. eCollection 2014 Oct.
BACKGROUND
Mean platelet volume (MPV) is generally accepted as a new marker of cardiovascular disease risk in several studies.
OBJECTIVES
This study aimed to determine the association of MPV with androgen hormones and insulin resistance (IR) in nonobese patients with polycystic ovary syndrome (PCOS).
PATIENTS AND METHODS
A total of 136 patients with newly diagnosed reproductive-age PCOS (regarding the criteria of new PCOS phenotypes, based on the Rotterdam criteria) who were nonobese with the mean age of 25 years (25.39 ± 5.51) and mean body mass index (BMI) of 21 kg/m(2) (22.07 ± 2.13) were included. In addition, 59 healthy subjects with mean age of 26 years (22.07 ± 2.13) and mean BMI of 22 kg/m(2) (21.52 ± 3.84) were recruited as control. Total blood count (including MPV), total testosterone, free testosterone, dehydroepiandrosterone-sulfate (DHEAS), and androstenedione levels were recorded. IR was calculated from blood chemistry measurements of fasting insulin and glucose according to updated homeostasis model assessment.
RESULTS
No differences were observed in mean MPV values between patients and control group (9.02 fL (8.5-10.1) and 8.9 fL (7.7-9.1), respectively; P = 0.777). MPV values were similar among nonobese patients with and without IR and control subjects (P > 0.05). We detected significantly lower values of MPV in patients with hyperandrogenemia in comparison to patients with normal androgen levels (8.7 and 9.5 fL, P = 0.012). There was a negative correlation between total testosterone, DHEAS, and MPV (P = 0.016, r = -0.229; and P = 0.006, r = -0.261, respectively). Multiple logistic regression analyses confirmed the independence of these associations.
CONCLUSIONS
Our study revealed that nonobese women with and without PCOS have similar MPV values. While IR does not have any effect on MPV, elevated androgen levels are associated with a low MPV in nonobese patients with PCOS.
背景
在多项研究中，平均血小板体积（MPV）通常被认为是心血管疾病风险的一个新标志物。
目的
本研究旨在确定非肥胖型多囊卵巢综合征（PCOS）患者中MPV与雄激素及胰岛素抵抗（IR）之间的关联。
患者与方法
共纳入136例新诊断的育龄期PCOS患者（根据新的PCOS表型标准，基于鹿特丹标准），这些患者均为非肥胖型，平均年龄25岁（25.39±5.51），平均体重指数（BMI）为21kg/m²（22.07±2.13）。此外，招募了59例健康受试者作为对照，其平均年龄26岁（22.07±2.13），平均BMI为22kg/m²（21.52±3.84）。记录全血细胞计数（包括MPV）、总睾酮、游离睾酮、硫酸脱氢表雄酮（DHEAS）及雄烯二酮水平。根据更新的稳态模型评估，通过空腹胰岛素和血糖的血液化学测量计算IR。
结果
患者组与对照组的平均MPV值无差异（分别为9.02fL（8.5 - 10.1）和8.9fL（7.7 - 9.1）；P = 0.777）。有IR和无IR的非肥胖型患者及对照受试者的MPV值相似（P > 0.05）。与雄激素水平正常的患者相比，高雄激素血症患者的MPV值显著更低（8.7和9.5fL，P = 0.012）。总睾酮、DHEAS与MPV之间存在负相关（分别为P = 0.016，r = -0.229；P = 0.006，r = -0.261）。多元逻辑回归分析证实了这些关联的独立性。
结论
我们的研究表明，有或无PCOS的非肥胖女性具有相似的MPV值。虽然IR对MPV没有任何影响，但在非肥胖型PCOS患者中，雄激素水平升高与低MPV相关。
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