Çelik Ebru, Türkçüoğlu Ilgın, Ata Barış, Karaer Abdullah, Kırıcı Pınar, Eraslan Sevil, Taşkapan Çağatay, Berker Bülent
Department of Obstetrics and Gynecology, İnönü University School of Medicine, Malatya, Turkey.
Department of Obstetrics and Gynecology, Koç University School of Medicine, İstanbul, Turkey.
J Turk Ger Gynecol Assoc. 2016 Dec 1;17(4):201-208. doi: 10.5152/jtgga.2016.16133. eCollection 2016.
To compare the prevalence of various metabolic and cardiovascular risk factors and insulin resistance between polycystic ovary syndrome (PCOS) patients with or without hyperandrogenism.
This is a retrospective cross-sectional study involving women with PCOS as diagnosed according to the Androgen Excess (AE) Society definition (n=504) and women with normoandrogenemic PCOS (n=183). Anthropometrics, lipid profile, glucose, insulin, oral glucose tolerance test (OGTT), and reproductive hormone levels were evaluated.
Women with PCOS diagnosed according to the AE Society had a significantly higher prevalence of metabolic syndrome compared with the normoandrogenemic PCOS phenotype: odds ratio (OR) 2.95 [95% confidence interval (CI) 1.21-7.21]. There was no significant difference in the prevalence glucose intolerance test between the groups [OR: 2.15, 95% CI 0.71-6.56]. The prevalence of low high density lipoprotein (HDL)-cholesterol in the group under the AE-PCOS Society criteria was higher than that of the normoandrogenemic PCOS group [OR: 2.82, 95%CI 1.29-3.36].
The risks of metabolic syndrome and cardiovascular disease may vary among the phenotypes of PCOS based on the Rotterdam criteria. This new data may be of reference in informing women with PCOS, although further prospective studies are needed to validate this proposition.
比较有或无高雄激素血症的多囊卵巢综合征（PCOS）患者各种代谢和心血管危险因素的患病率以及胰岛素抵抗情况。
这是一项回顾性横断面研究，纳入了根据雄激素过多协会（AE）定义确诊的PCOS女性（n = 504）和正常雄激素水平的PCOS女性（n = 183）。评估了人体测量学指标、血脂谱、血糖、胰岛素、口服葡萄糖耐量试验（OGTT）和生殖激素水平。
根据AE协会诊断的PCOS女性与正常雄激素水平的PCOS表型相比，代谢综合征的患病率显著更高：比值比（OR）为2.95 [95%置信区间（CI）为1.21 - 7.21]。两组之间葡萄糖耐量试验的患病率无显著差异[OR：2.15，95% CI为0.71 - 6.56]。符合AE - PCOS协会标准组的低高密度脂蛋白（HDL）胆固醇患病率高于正常雄激素水平的PCOS组[OR：2.82，95% CI为1.29 - 3.36]。
基于鹿特丹标准，PCOS不同表型的代谢综合征和心血管疾病风险可能有所不同。这些新数据可能为告知PCOS女性提供参考，尽管还需要进一步的前瞻性研究来验证这一观点。
