Shojima M, Oshima M, Takagi K, Hayakawa M, Katada K, Morita A, Kirino T
Department of Neurosurgery and Institute of Industrial Science, University of Tokyo, Tokyo; Japan.
Interv Neuroradiol. 2006 Jan 20;12(Suppl 1):49-52. doi: 10.1177/15910199060120S105. Epub 2006 Jun 15.
Intra-aneurysmal flow dynamics is analyzed qualitatively and quantitatively with numerical simulation technique, and presented for the future clinical application in embolizing cerebral aneurysms. From the volumetric data obtained by three-dimensional computed tomographic angiography, patient-specific vessel models were created for 16 middle cerebral artery aneurysms. Intraaneurysmal flow dynamics was visualized and analyzed qualitatively, and the geometrical parameters of vessels and aneurysms that affect the intra- aneurysmal flow dynamics were determined quantitatively by correlation analysis. The flow velocity was delayed in the aneurysm cavity, especially at its tip where the rupture usually occurs. The intra-aneurysmal flow dynamics was considerably influenced by the geometrical parameters that are related to the width of the neck and the branching angle of larger branch artery. The intra-aneurysmal flow dynamics is complex, and the numerical flow simulations with patient-specific vascular models seems effective in understanding the flow dynamics and planning the endovascular treatment of cerebral aneurysms.
采用数值模拟技术对动脉瘤内血流动力学进行定性和定量分析，并展示其在未来脑动脉瘤栓塞临床应用中的情况。根据三维计算机断层血管造影获得的容积数据，为16个大脑中动脉动脉瘤创建了个体化血管模型。对动脉瘤内血流动力学进行定性可视化和分析，并通过相关性分析定量确定影响动脉瘤内血流动力学的血管和动脉瘤几何参数。动脉瘤腔内的血流速度延迟，尤其是在通常发生破裂的瘤顶处。动脉瘤内血流动力学受与瘤颈宽度和较大分支动脉分支角度相关的几何参数显著影响。动脉瘤内血流动力学复杂，基于个体化血管模型的数值血流模拟似乎有助于理解血流动力学并规划脑动脉瘤的血管内治疗。
