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生物模拟与可视化:脑血管几何结构对血流动力学的影响

Biosimulation and visualization: effect of cerebrovascular geometry on hemodynamics.

作者信息

Oshima Marie, Kobayashi Toshio, Takagi Kiyoshi

机构信息

Institute of Industrial Science, University of Tokyo, Japan.

出版信息

Ann N Y Acad Sci. 2002 Oct;972:337-44. doi: 10.1111/j.1749-6632.2002.tb04593.x.

DOI:10.1111/j.1749-6632.2002.tb04593.x
PMID:12496038
Abstract

Hemodynamics plays an important role in cardiovascular disorders, and the authors are applying numerical and experimental studies of cerebrovascular blood flow to the creation and rupture of cerebral aneurysms. In particular, this study aims to investigate the effects of cerebrovascular geometry on hemodynamics, such as flow pattern, wall shear stress distribution, and pressure. This report consists mainly of two parts: numerical study of blood flow in the artery extracted from computer tomography data, and numerical and experimental studies of a curved pipe model. The simulation was conducted by using a finite element method; the experiment was conducted by particle imaging velocimetry. Numerical and experimental results are compared and both show similar secondary flow behavior.

摘要

血流动力学在心血管疾病中起着重要作用,作者正在将脑血管血流的数值和实验研究应用于脑动脉瘤的形成和破裂。特别是,本研究旨在探讨脑血管几何形状对血流动力学的影响,如流动模式、壁面剪应力分布和压力。本报告主要由两部分组成:从计算机断层扫描数据中提取的动脉血流数值研究,以及弯曲管道模型的数值和实验研究。模拟采用有限元方法进行;实验采用粒子图像测速法进行。对数值和实验结果进行了比较,两者均显示出相似的二次流动行为。

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