Clerico A, Jenkner A, Castello M A, Ciofetta G, Lucarelli C, Codini M
Department of Pediatrics, University La Sapienza, Rome, Italy.
Med Pediatr Oncol. 1991;19(4):329-33. doi: 10.1002/mpo.2950190421.
Ganglioneuromas are usually considered not to be functionally active. Studies of their catecholamine excretory pattern and of their imaging by means of the adrenergic tracing agent 131-I-MIBG have been therefore sparse. We report on a case of secretory ganglioneuroma, as demonstrated by the increased urinary excretion of the catecholamine metabolites HVA and VMA, increased plasma dopamine and epinephrine levels, and positive 131-I-MIBG scintigraphy. We must therefore be aware that a functionally active tumor is not necessarily a neuroblastoma, and that the diagnosis should be biopsy proven.
神经节神经瘤通常被认为没有功能活性。因此，关于其儿茶酚胺排泄模式以及通过肾上腺素能示踪剂131-I-间碘苄胍（131-I-MIBG）进行成像的研究很少。我们报告一例分泌性神经节神经瘤，表现为儿茶酚胺代谢产物高香草酸（HVA）和香草扁桃酸（VMA）的尿排泄增加、血浆多巴胺和肾上腺素水平升高以及131-I-MIBG闪烁显像阳性。因此，我们必须意识到功能活跃的肿瘤不一定是神经母细胞瘤，诊断应经活检证实。
