• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

脓毒症对早产儿免疫反应、微生物群和氧化代谢的影响。

Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants.

作者信息

Parra-Llorca Anna, Pinilla-Gonzlez Alejandro, Torrejón-Rodríguez Laura, Lara-Cantón Inmaculada, Kuligowski Julia, Collado María Carmen, Gormaz María, Aguar Marta, Vento Máximo, Serna Eva, Cernada María

机构信息

Division of Neonatology, University and Polytechnic Hospital La Fe (HULAFE), 46026 Valencia, Spain.

Neonatal Research Group, Health Research Institute La Fe (IISLAFE), 46026 Valencia, Spain.

出版信息

Children (Basel). 2023 Mar 22;10(3):602. doi: 10.3390/children10030602.

DOI:10.3390/children10030602
PMID:36980160
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10046958/
Abstract

This is a narrative review about the mechanisms involved in bacterial sepsis in preterm infants, which is an illness with a high incidence, morbidity, and mortality. The role of the innate immune response and its relationship with oxidative stress in the pathogenesis are described as well as their potential implementation as early biomarkers. Moreover, we address the impact that all the mechanisms triggered by sepsis have on the dysbiosis and the changes on neonatal microbiota.

摘要

这是一篇关于早产儿细菌性败血症相关机制的叙述性综述，细菌性败血症是一种发病率、发病率和死亡率都很高的疾病。文中描述了先天性免疫反应的作用及其在发病机制中与氧化应激的关系，以及它们作为早期生物标志物的潜在应用。此外，我们还探讨了败血症引发的所有机制对新生儿微生物群失调和变化的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4875/10046958/83b8f75822fa/children-10-00602-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4875/10046958/83b8f75822fa/children-10-00602-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4875/10046958/83b8f75822fa/children-10-00602-g001.jpg

相似文献

1
Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants.脓毒症对早产儿免疫反应、微生物群和氧化代谢的影响。
Children (Basel). 2023 Mar 22;10(3):602. doi: 10.3390/children10030602.
2
Neonatal sepsis and the skin microbiome.新生儿败血症与皮肤微生物组。
J Perinatol. 2022 Nov;42(11):1429-1433. doi: 10.1038/s41372-022-01451-0. Epub 2022 Jul 11.
3
Gut Dysbiosis, Bacterial Colonization and Translocation, and Neonatal Sepsis in Very-Low-Birth-Weight Preterm Infants.极低出生体重早产儿的肠道菌群失调、细菌定植与易位及新生儿败血症
Front Microbiol. 2021 Oct 7;12:746111. doi: 10.3389/fmicb.2021.746111. eCollection 2021.
4
Sepsis in preterm infants causes alterations in mucosal gene expression and microbiota profiles compared to non-septic twins.与非感染性双胞胎相比，早产儿脓毒症会引起黏膜基因表达和微生物组谱的改变。
Sci Rep. 2016 May 16;6:25497. doi: 10.1038/srep25497.
5
Perinatal Antibiotic Exposure Affects the Transmission between Maternal and Neonatal Microbiota and Is Associated with Early-Onset Sepsis.围产期抗生素暴露会影响母婴微生物群之间的传播，并与早发性败血症有关。
mSphere. 2020 Feb 19;5(1):e00984-19. doi: 10.1128/mSphere.00984-19.
6
Efficacy of probiotics to prevent gut dysbiosis in preterm infants of 28+0-32+6 weeks of gestation: a randomised, placebo-controlled, double-blind, multicentre trial: the PRIMAL Clinical Study protocol.早产儿（胎龄 28+0-32+6 周）应用益生菌预防肠道菌群失调的疗效：一项随机、安慰剂对照、双盲、多中心试验：PRIMAL 临床研究方案。
BMJ Open. 2019 Nov 21;9(11):e032617. doi: 10.1136/bmjopen-2019-032617.
7
Gut Dysbiosis With Bacilli Dominance and Accumulation of Fermentation Products Precedes Late-onset Sepsis in Preterm Infants.双歧杆菌优势和发酵产物积累引起的肠道菌群失调先于早产儿晚发性败血症。
Clin Infect Dis. 2019 Jul 2;69(2):268-277. doi: 10.1093/cid/ciy882.
8
Gut microbiome dysbiosis in neonatal sepsis.新生儿败血症中的肠道微生物组失调。
Prog Mol Biol Transl Sci. 2022;192(1):125-147. doi: 10.1016/bs.pmbts.2022.07.010. Epub 2022 Aug 30.
9
Necrotizing Enterocolitis and the Preterm Infant Microbiome.坏死性小肠结肠炎与早产儿肠道微生物组。
Adv Exp Med Biol. 2019;1125:25-36. doi: 10.1007/5584_2018_313.
10
Antimicrobial Peptides (AMPs) and the Microbiome in Preterm Infants: Consequences and Opportunities for Future Therapeutics.抗菌肽 (AMPs) 和早产儿微生物组：未来治疗的后果和机遇。
Int J Mol Sci. 2024 Jun 18;25(12):6684. doi: 10.3390/ijms25126684.

引用本文的文献

1
Molecular Mechanisms Underlying Inflammation in Early-Onset Neonatal Sepsis: A Systematic Review of Human Studies.早发型新生儿败血症炎症的分子机制：人类研究的系统综述
J Clin Med. 2025 Jul 28;14(15):5315. doi: 10.3390/jcm14155315.
2
Hemoglobin, Ferritin, and Lactate Dehydrogenase as Predictive Markers for Neonatal Sepsis.血红蛋白、铁蛋白和乳酸脱氢酶作为新生儿败血症的预测标志物
J Pers Med. 2024 Apr 29;14(5):476. doi: 10.3390/jpm14050476.
3
Predictive Value of Inflammatory Markers NLR, PLR, APRI, SII, and Liver Function Tests in Systemic Inflammatory Response Syndrome Detection in Full-Term Newborns.

本文引用的文献

1
Incidence of and Neurodevelopmental Outcomes After Late-Onset Meningitis Among Children Born Extremely Preterm.极早产儿晚发型脑膜炎的发病情况及神经发育结局。
JAMA Netw Open. 2022 Dec 1;5(12):e2245826. doi: 10.1001/jamanetworkopen.2022.45826.
2
Procalcitonin for sepsis management: Implementation within an antimicrobial stewardship program.降钙素原在脓毒症管理中的应用：在抗菌药物管理计划中的实施。
Am J Health Syst Pharm. 2023 May 24;80(Suppl 2):S49-S54. doi: 10.1093/ajhp/zxac341.
3
Updates in Late-Onset Sepsis: Risk Assessment, Therapy, and Outcomes.
炎症标志物NLR、PLR、APRI、SII及肝功能检查对足月儿全身炎症反应综合征的预测价值
Children (Basel). 2024 May 14;11(5):593. doi: 10.3390/children11050593.
4
Necrotizing enterocolitis, gut microbes, and sepsis.坏死性小肠结肠炎，肠道微生物，和脓毒症。
Gut Microbes. 2023 Jan-Dec;15(1):2221470. doi: 10.1080/19490976.2023.2221470.
5
Maternal and Neonatal Factors Modulating Breast Milk Cytokines in the First Month of Lactation.哺乳期第一个月调节母乳细胞因子的母婴因素
Antioxidants (Basel). 2023 Apr 25;12(5):996. doi: 10.3390/antiox12050996.
晚期脓毒症的最新进展：风险评估、治疗和预后。
Neoreviews. 2022 Nov 1;23(11):738-755. doi: 10.1542/neo.23-10-e738.
4
Neonatal Early-Onset Sepsis.新生儿早发性败血症。
Neoreviews. 2022 Nov 1;23(11):756-770. doi: 10.1542/neo.23-10-e756.
5
The Value of Perinatal Factors, Blood Biomarkers and Microbiological Colonization Screening in Predicting Neonatal Sepsis.围产期因素、血液生物标志物及微生物定植筛查在预测新生儿败血症中的价值
J Clin Med. 2022 Oct 1;11(19):5837. doi: 10.3390/jcm11195837.
6
Early molecular markers of ventilator-associated pneumonia in bronchoalveolar lavage in preterm infants.早产儿支气管肺泡灌洗液中呼吸机相关性肺炎的早期分子标志物。
Pediatr Res. 2023 May;93(6):1559-1565. doi: 10.1038/s41390-022-02271-w. Epub 2022 Sep 7.
7
Association of Procalcitonin to Albumin Ratio with the Presence and Severity of Sepsis in Neonates.降钙素原与白蛋白比值与新生儿脓毒症的存在及严重程度的关联
J Inflamm Res. 2022 Apr 12;15:2313-2321. doi: 10.2147/JIR.S358067. eCollection 2022.
8
Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers.新生儿败血症的诊断：炎症标志物的作用
Front Pediatr. 2022 Mar 8;10:840288. doi: 10.3389/fped.2022.840288. eCollection 2022.
9
Differential Gene Sets Profiling in Gram-Negative and Gram-Positive Sepsis.革兰氏阴性菌和革兰氏阳性菌脓毒症的差异基因集分析。
Front Cell Infect Microbiol. 2022 Feb 9;12:801232. doi: 10.3389/fcimb.2022.801232. eCollection 2022.
10
Novel Treatments Targeting the Dysregulated Cell Signaling Pathway during Sepsis.针对脓毒症期间失调细胞信号通路的新型治疗方法。
J Cell Signal. 2021 Dec;2(4):228-234.