Ayanian J Z, Epstein A M
Department of Medicine, Brigham and Women's Hospital, Boston, MA.
N Engl J Med. 1991 Jul 25;325(4):221-5. doi: 10.1056/NEJM199107253250401.
Previous studies at individual hospitals have reported differences in the use of major diagnostic and therapeutic procedures for women and men with coronary heart disease. To assess whether these differences can be generalized, we performed retrospective analyses of coronary angiography and revascularization (coronary-artery bypass surgery or percutaneous transluminal coronary angioplasty) in women and men hospitalized for coronary heart disease in 1987, using abstract data on 49,623 discharges in Massachusetts and 33,159 discharges in Maryland. We used multiple logistic regression to estimate the adjusted odds of the use of a procedure, controlling for principal diagnosis, age, secondary diagnosis of congestive heart failure or diabetes mellitus, race, and insurance status.
The adjusted odds of undergoing angiography were 28 percent and 15 percent higher for men than for women in Massachusetts and Maryland, respectively (95 percent confidence intervals for the odds ratios, 1.22 to 1.35 and 1.08 to 1.22). The respective adjusted odds of undergoing revascularization were 45 percent and 27 percent higher for men than for women (95 percent confidence intervals, 1.35 to 1.55 and 1.16 to 1.40). Because these differences could be related to differing thresholds for hospital admission, we performed a second analysis limited to patients with diagnosed acute myocardial infarction (11,865 discharges in Massachusetts and 6894 discharges in Maryland), a group in which all patients would be expected to receive hospital care. The male-to-female odds ratios in both states remained similar in magnitude and were statistically significant for angiography and revascularization.
These findings demonstrate that women who are hospitalized for coronary heart disease undergo fewer major diagnostic and therapeutic procedures than men. These differences may represent appropriate levels of care for men and women, but it is also possible that they reflect underuse in women or overuse in men. Further study should assess the cause of these differences and their effect on patients' outcomes.
此前在个别医院开展的研究报告称,患有冠心病的女性和男性在主要诊断和治疗程序的使用上存在差异。为评估这些差异是否具有普遍性,我们利用马萨诸塞州49623例出院病例以及马里兰州33159例出院病例的摘要数据,对1987年因冠心病住院的女性和男性进行了冠状动脉造影和血运重建术(冠状动脉搭桥手术或经皮冠状动脉腔内血管成形术)的回顾性分析。我们使用多元逻辑回归来估计接受某项程序的调整后比值比,同时控制主要诊断、年龄、充血性心力衰竭或糖尿病的次要诊断、种族和保险状况。
在马萨诸塞州和马里兰州,男性接受血管造影的调整后比值比分别比女性高28%和15%(比值比的95%置信区间分别为1.22至1.35和1.08至1.22)。男性接受血运重建术的相应调整后比值比分别比女性高45%和27%(95%置信区间分别为1.35至1.55和1.16至1.40)。由于这些差异可能与不同的住院阈值有关,我们进行了第二项分析,仅限于诊断为急性心肌梗死的患者(马萨诸塞州11865例出院病例,马里兰州6894例出院病例),这组患者预计都会接受住院治疗。两个州的男性与女性比值比在幅度上仍然相似,并且在血管造影和血运重建术方面具有统计学意义。
这些发现表明,因冠心病住院的女性接受的主要诊断和治疗程序比男性少。这些差异可能代表了对男性和女性适当的治疗水平,但也有可能反映出女性治疗不足或男性治疗过度。进一步的研究应评估这些差异的原因及其对患者预后的影响。