Memory and Alzheimer's Disease Unit, Instituto Andaluz de Neurociencia y Conducta, Alamos, 17, 29012 Malaga, Spain.
Arch Gerontol Geriatr. 2011 May-Jun;52(3):264-9. doi: 10.1016/j.archger.2010.05.004. Epub 2010 Jun 8.
The authors performed a cross-sectional study to examine the relationship between specific cognitive domains and behavioral and psychological symptoms in dementia (BPSD) in 125 patients with probable AD. Cognitive deficits were evaluated with the mini mental state examination (MMSE), trail-making test (TMT), Rey auditory verbal learning test (RAVLT), and semantic fluency test (SFT) and phonemic fluency test (PhFT), whereas the neuropsychiatric inventory (NPI) was used to rate BPSD. Patients' performance in cognitive tests significantly correlated with total NPI scores (p<0.0001). After controlling for demographic and clinical characteristics, cognitive impairments in memory, executive function, and language (RAVLT, TMT, PhFT, SFT) importantly estimated total NPI scores (p<0.001, multivariate regression models). These findings suggest that the evaluation of cognitive domains may have a predictive value for the occurrence of BPSD.
作者进行了一项横断面研究，以检查 125 例可能患有 AD 的患者中特定认知领域与痴呆（BPSD）的行为和心理症状之间的关系。认知缺陷通过简易精神状态检查（MMSE）、连线测试（TMT）、 Rey 听觉言语学习测验（RAVLT）和语义流畅性测验（SFT）和语音流畅性测验（PhFT）进行评估，而神经精神科问卷（NPI）用于评估 BPSD。患者在认知测试中的表现与 NPI 总分显著相关（p<0.0001）。在控制人口统计学和临床特征后，记忆、执行功能和语言方面的认知障碍（RAVLT、TMT、PhFT、SFT）重要地预测了 NPI 总分（p<0.001，多元回归模型）。这些发现表明，认知领域的评估可能对 BPSD 的发生具有预测价值。
