Laboratoire de Neurobiologie des Processus Adaptatifs, CNRS UMR 7102, Navigation, Memory and Aging team, UPMC, 9 quai Saint Bernard, Paris, France.
Behav Brain Res. 2010 Dec 31;215(2):172-9. doi: 10.1016/j.bbr.2010.05.054. Epub 2010 Jun 4.
One of the crucial issues in actual research on memory disorders and particularly in Alzheimer's disease is the development of behavioral tasks accurately testing episodic memory, a type of memory sensitive to aging and altered early during neurodegenerative disorders. Translational research allowing comparison of similar memory properties between human and rodent models is a requirement for the finding of behavioral and cognitive biomarkers as well as molecular deficits associated to the pathology. In this review, we propose that the ability to remember an ordered sequence of choices during spatial navigation could be one of the episodic memory properties shared by human and rodent models. The ability to learn the correct sequence of choices depends on the hippocampus, requires flexibility and is particularly sensitive to age-related decline in rodents as in humans. In an innovative approach, we took advantage of a well characterized rodent navigation task, the starmaze, to develop a new model of episodic allowing creating and objective experimental testing of a personal past experience without requiring verbal report which can be transferred to human.
在记忆障碍的实际研究中，尤其是在阿尔茨海默病的研究中，一个关键问题是开发行为任务，以准确测试情景记忆，这是一种对衰老敏感且在神经退行性疾病早期发生改变的记忆类型。允许在人类和啮齿动物模型之间比较类似记忆特性的转化研究，是发现与病理学相关的行为和认知生物标志物以及分子缺陷的必要条件。在这篇综述中，我们提出，在空间导航过程中记住有序选择序列的能力可能是人类和啮齿动物模型共有的情景记忆特性之一。学习正确选择序列的能力取决于海马体，需要灵活性，并且在啮齿动物中对与年龄相关的下降特别敏感，就像在人类中一样。在一种创新的方法中，我们利用一种特征明确的啮齿动物导航任务——星迷宫，开发了一种新的情景记忆模型，该模型允许在不要求口头报告的情况下创建和客观地测试个人过去的经历，而口头报告可以转移到人类。
