New York State Psychiatric Institute, New York, NY 10032, USA.
Appetite. 2010 Oct;55(2):214-8. doi: 10.1016/j.appet.2010.05.090. Epub 2010 Jun 4.
Anorexia nervosa (AN) is a serious mental illness characterized by reduced caloric intake that often persists after acute weight restoration. This preliminary study assesses the relationship between pre-meal anxiety and food intake in recently weight-restored individuals with AN. We hypothesized that pre-meal anxiety is inversely related to caloric intake in AN. Caloric intake and pre-meal anxiety were measured in three laboratory-based assessments (yogurt snack, multi-item lunch, macaroni and cheese lunch). Anxiety was measured by Spielberger State-Trait Anxiety Inventory (STAI-S) administered prior to the meal. Acutely weight-restored patients with AN were compared with healthy controls (HCs). Associations between anxiety and intake were analyzed first within each meal type separately and then using a model to combine the sample. In the multi-item lunch and the macaroni and cheese lunch, AN ate significantly less than HC (p=0.01, p<0.001). Pre-meal anxiety was significantly correlated with intake among AN, but not HC. In the yogurt snack, there was no significant association between anxiety and intake among patients or controls, and the groups did not differ in caloric intake. The association between pre-meal anxiety and intake among weight-restored individuals with AN suggests a potential target for relapse prevention treatment.
神经性厌食症（AN）是一种严重的精神疾病，其特征是热量摄入减少，且在急性体重恢复后往往持续存在。本初步研究评估了 AN 患者体重恢复后餐前焦虑与食物摄入之间的关系。我们假设，餐前焦虑与 AN 患者的热量摄入呈负相关。在三项基于实验室的评估中（酸奶零食、多项午餐、通心粉和奶酪午餐）测量了热量摄入和餐前焦虑。在用餐之前，通过 Spielberger 状态-特质焦虑量表（STAI-S）来测量焦虑。将急性体重恢复的 AN 患者与健康对照（HC）进行比较。首先在每种膳食类型内分别分析焦虑与摄入量之间的关联，然后使用模型将样本组合在一起进行分析。在多项午餐和通心粉和奶酪午餐中，AN 组的摄入量明显少于 HC 组（p=0.01，p<0.001）。在 AN 组中，餐前焦虑与摄入量显著相关，但在 HC 组中没有显著相关性。在酸奶零食中，患者和对照组之间的焦虑与摄入量之间没有显著关联，且两组的热量摄入量没有差异。AN 患者体重恢复后餐前焦虑与摄入量之间的关联表明，这可能是预防复发治疗的一个潜在靶点。
