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前列腺放射治疗中的活体实时直肠壁剂量测定。

In vivo real-time rectal wall dosimetry for prostate radiotherapy.

机构信息

Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.

出版信息

Phys Med Biol. 2010 Jul 7;55(13):3859-71. doi: 10.1088/0031-9155/55/13/019.

Abstract

Rectal balloons are used in external beam prostate radiotherapy to provide reproducible anatomy and rectal dose reductions. This is an investigation into the combination of a MOSFET radiation detector with a rectal balloon for realtime in vivo rectal wall dosimetry. The MOSFET used in the study is a radiation detector that provides a water equivalent depth of measurement of 70 microm. Two MOSFETs were combined in a face-to-face orientation. The reproducibility, sensitivity and angular dependence were measured for the dual MOSFET in a 6 MV photon beam. The dual MOSFET was combined with a rectal balloon and irradiated with hypothetical prostate treatments in a phantom. The anterior rectal wall dose was measured in real time and compared with the planning system calculated dose. The dual MOSFET showed angular dependence within +/-2.5% in the azimuth and +2.5%/-4% in the polar axes. When compared with an ion chamber measurement in a phantom, the dual MOSFET agreed within 2.5% for a range of radiation path lengths and incident angles. The dual MOSFET had reproducible sensitivity for fraction sizes of 2-10 Gy. For the hypothetical prostate treatments the measured anterior rectal wall dose was 2.6 and 3.2% lower than the calculated dose for 3DCRT and IMRT plans. This was expected due to limitations of the dose calculation method used at the balloon cavity interface. A dual MOSFET combined with a commercial rectal balloon was shown to provide reproducible measurements of the anterior rectal wall dose in real time. The measured anterior rectal wall dose agreed with the expected dose from the treatment plan for 3DCRT and IMRT plans. The dual MOSFET could be read out in real time during the irradiation, providing the capability for real-time dose monitoring of the rectal wall dose during treatment.

摘要

直肠球囊用于外照射前列腺放射治疗,以提供可重复的解剖结构和直肠剂量降低。这是一项关于 MOSFET 辐射探测器与直肠球囊结合用于实时体内直肠壁剂量测量的研究。研究中使用的 MOSFET 是一种辐射探测器,可提供 70 微米的水当量深度测量。两个 MOSFET 面对面组合在一起。在 6MV 光子束中测量了双 MOSFET 的可重复性、灵敏度和角度依赖性。将双 MOSFET 与直肠球囊结合,并在模体中用假设的前列腺治疗进行照射。实时测量前直肠壁剂量,并与计划系统计算的剂量进行比较。双 MOSFET 在方位角内的角度依赖性为 +/-2.5%,极轴内为+2.5%/-4%。与模体中的离子室测量相比,双 MOSFET 在一定范围内的辐射路径长度和入射角内,测量结果在 2.5%以内。双 MOSFET 对于 2-10Gy 的分次剂量具有可重复的灵敏度。对于假设的前列腺治疗,测量的前直肠壁剂量比 3DCRT 和 IMRT 计划的计算剂量低 2.6%和 3.2%。这是由于在球囊腔界面使用的剂量计算方法的限制所致。结果表明,双 MOSFET 与商业直肠球囊结合,可实时提供前直肠壁剂量的可重复测量。测量的前直肠壁剂量与 3DCRT 和 IMRT 计划的治疗计划预期剂量相符。双 MOSFET 可以在照射过程中实时读取,从而为治疗期间直肠壁剂量的实时剂量监测提供了可能性。

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