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[氯化镁与抗氧化剂联合给药对长期高胆固醇血症的血管保护作用]

[The vascular protective effect of the combined administration of magnesium chloride and antioxidants in prolonged hypercholesterolemia ].

作者信息

Talaieva T V, Taranenko V M, Isaiechkina I M, Tyshkin S M, Sergiienko O V, Tretiak I V, Bratus V V

出版信息

Fiziol Zh (1978). 1993 Jan-Feb;39(1):102-6.

PMID:8335117
Abstract

The angioprotective efficacy of combined application of magnesium chloride and antioxidants during prolonged hypercholesterolemia has been investigated on the experimental model of atherosclerosis in rabbits. The application of magnesium chloride and acetate tocopherol from the very beginning of the atherogenic diet is shown to exert a pronounced angioprotective effect preventing the development of structural and functional changes in the aorta wall. If the treatment is initiated against the background of the well developed atherosclerotic symptoms, its efficacy is less pronounced but remains still on a quite high level. These data indicate that combination of magnesium chloride and antioxidants has not only protective action but can also induce partial regression of the developed atherosclerotic changes.

摘要

在兔动脉粥样硬化实验模型上,研究了氯化镁与抗氧化剂联合应用在长期高胆固醇血症期间的血管保护作用。结果表明,从致动脉粥样硬化饮食开始就应用氯化镁和生育酚醋酸酯,可发挥显著的血管保护作用,防止主动脉壁出现结构和功能变化。如果在动脉粥样硬化症状已充分发展的背景下开始治疗,其效果虽不那么显著,但仍处于相当高的水平。这些数据表明,氯化镁与抗氧化剂的组合不仅具有保护作用,还可诱导已发生的动脉粥样硬化变化部分消退。

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