National Institute of Malaria Research, ICMR Complex, Poojanahalli, Kannamangala Post, Devanahalli, Bangalore, 562110, Karnataka, India.
Malar J. 2010 Jun 23;9:179. doi: 10.1186/1475-2875-9-179.
Synthetic pyrethroids are potent insecticides most commonly used in the vector control programme. These are applied for indoor residual sprays, space sprays and in impregnated bed nets. Resistance reduces the efficacy of insecticides. Thus, the susceptibility status of the target vector(s) is monitored routinely to select the effective ones. A study was undertaken in a malaria endemic coastal city Mangalore, Karnataka, South India, against the known malaria vector Anopheles stephensi.
The susceptibility status was assessed at diagnostic doses of DDT (4%), malathion (5%), deltamethrin (0.05%), cyfluthrin (0.15%), alphacypermethrin (0.10%), lambdacyhalothrin (0.05%) and permethrin (0.75%) using the standard WHO tube test method during October/November 2006.
Anopheles stephensi was resistant to malathion by 54.9%, but tolerant to deltamethrin by 86.1%, cyfluthrin 95.5% and alphacypermethrin 90.6%, whereas it was susceptible to DDT by 98.1%, lambdacyhalothrin 98.6% and permethrin 100.0%, respectively. The KDT50 and KDT95 values for these insecticides also showed the similar responses.
Susceptibility of An. stephensi to DDT is an important finding as this has never been used in Mangalore city, whereas its rural counterpart Anopheles culicifacies is widely resistant to this insecticide. The study explores the selection and rotation of the appropriate insecticide molecule even within the same group for effective vector management.
拟除虫菊酯是最常用于病媒控制计划的强效杀虫剂。它们被用于室内残留喷雾、空间喷雾和浸渍蚊帐中。抗药性降低了杀虫剂的效果。因此，通常会监测目标病媒（s）的敏感性状况，以选择有效的杀虫剂。在印度南部卡纳塔克邦的疟疾流行沿海城市芒格洛尔进行了一项针对已知疟疾传播媒介按蚊斯蒂芬斯的研究。
在 2006 年 10 月至 11 月期间，使用标准世界卫生组织管测试方法，在诊断剂量的滴滴涕（4%）、马拉硫磷（5%）、溴氰菊酯（0.05%）、氯氟氰菊酯（0.15%）、高效氯氟氰菊酯（0.10%）、氯菊酯（0.05%）和氯菊酯（0.75%）下评估了敏感性状况。
按蚊对马拉硫磷的抗性为 54.9%，但对溴氰菊酯的耐受性为 86.1%，对氯氟氰菊酯为 95.5%，对高效氯氟氰菊酯为 90.6%，而对滴滴涕的敏感性为 98.1%，对氯菊酯的敏感性为 98.6%，对氯菊酯的敏感性为 100.0%。这些杀虫剂的 KDT50 和 KDT95 值也显示出类似的反应。
按蚊对滴滴涕的敏感性是一个重要发现，因为滴滴涕从未在芒格洛尔市使用过，而其农村对应物库蚊对这种杀虫剂广泛具有抗性。该研究探索了在同一组内选择和轮换适当的杀虫剂分子，以进行有效的病媒管理。
