Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Denmark.
Acta Derm Venereol. 2010 Jul;90(4):341-9. doi: 10.2340/00015555-0905.
Psoriasis is a chronic inflammatory skin disease, which affects approximately 2.6% of the population in Northern Europe and Scandinavia. In order to achieve disease control, combinations of systemic treatments are sometimes needed for variable time periods. However, no evidence-based guidelines exist for the use of systemic combination therapy. Therefore, our aim was to review the current literature on systemic anti-psoriatic combination regimens. We searched PubMed and identified 98 papers describing 116 studies (23 randomized) reporting on the effect of various systemic combination treatments. The most thoroughly investigated combination was retinoid and phototherapy. Further controlled research is needed to define the safest and most effective combination regimens.
银屑病是一种慢性炎症性皮肤病，在北欧和斯堪的纳维亚地区，大约有 2.6%的人患有这种病。为了控制疾病，有时需要使用全身性治疗药物并持续一段时间。然而，目前还没有针对全身性联合治疗药物使用的循证指南。因此，我们的目的是回顾当前关于全身性抗银屑病联合治疗方案的文献。我们在 PubMed 上进行了检索，确定了 98 篇描述了 116 项研究（23 项为随机研究）的文献，这些研究报告了各种全身性联合治疗的效果。研究最深入的联合治疗是维 A 酸和光疗。需要进一步进行对照研究来确定最安全和最有效的联合治疗方案。
