Kudryavtseva N N, Bakshtanovskaya I V, Koryakina L A
Institute of Cytology and Genetics, Siberian Department of USSR Academy of Sciences, Novosibirsk.
Pharmacol Biochem Behav. 1991 Feb;38(2):315-20. doi: 10.1016/0091-3057(91)90284-9.
Long experience of defeat in daily social intermale confrontations and permanent living with aggressive males under sensory contact conditions [Kudryavtseva (8)] has been shown to produce changes in the patterns of submissive behavior of male mice of C57BL/6J strain. The submissive males after 20 defeats demonstrated passive defense postures instead of active defense and withdrawal which they had displayed in first encounters. Moreover, new immobile postures appeared, which were very rare in the first confrontations. Submissive animals displayed a decrease of ambulation in the open-field test and increase the immobility time in the Porsolt's test. Chronic treatment with imipramine prevented the increase of "depressiveness" estimated by means of the Porsolt's test. There was a loss of weight and some disturbances in gastrointestinal functions. The data are discussed in terms of the development of depression in submissive male C57BL/6J mice as a result of chronic unavoidable social stress.
在日常社会雄性间对抗中长期经历失败，以及在感官接触条件下与具有攻击性的雄性长期生活在一起[库德里亚夫采娃（8）]，已被证明会使C57BL/6J品系雄性小鼠的顺从行为模式发生变化。在经历20次失败后，顺从的雄性小鼠表现出被动防御姿势，而不是它们在初次遭遇时所表现出的主动防御和退缩。此外，还出现了新的静止姿势，这在初次对抗中非常罕见。顺从的动物在旷场试验中活动减少，在波索尔特试验中静止时间增加。用丙咪嗪进行慢性治疗可防止通过波索尔特试验评估的“抑郁程度”增加。体重减轻，胃肠功能出现一些紊乱。这些数据是从顺从的雄性C57BL/6J小鼠因慢性不可避免的社会压力而导致抑郁发展的角度进行讨论的。
