UCLA Stroke Center and Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Pharmacotherapy. 2010 Jul;30(7 Pt 2):62S-9S. doi: 10.1592/phco.30.pt2.62S.
Many treatments for acute ischemic stroke are vessel and blood based, but brain-based therapies also hold great promise. Acute neuroprotective therapies block the molecular elaboration of injury in hypoxic environments. Prehospital trials of magnesium sulfate are demonstrating the feasibility of delivering potentially brain-protective agents in the first minutes after stroke onset. Subacute neurorestoration therapies enhance neuroplasticity and brain reorganization after stroke. The greatest clinical experience with agents that can potentiate brain repair has been gained with choline precursors. Therapies that target the brain in patients with stroke will increasingly complement and enhance traditional vasotherapeutics.
许多急性缺血性脑卒中的治疗方法基于血管和血液，但基于大脑的治疗方法也具有很大的前景。急性神经保护疗法可阻断缺氧环境下损伤的分子表达。硫酸镁的院前试验表明，在中风发作后的最初几分钟内，有可能提供神经保护剂。亚急性神经修复疗法可增强中风后的神经可塑性和大脑重组。在可以增强大脑修复的药物中，胆碱前体的临床经验最多。针对中风患者大脑的治疗方法将越来越多地补充和增强传统的血管治疗方法。
