State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, People's Republic of China.
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, People's Republic of China.
Eur J Pharmacol. 2020 Nov 5;886:173546. doi: 10.1016/j.ejphar.2020.173546. Epub 2020 Sep 12.
Magnesium as an enzymatic activator is essential for various physiological functions such as cell cycle, metabolic regulation, muscle contraction, and vasomotor tone. A growing body of evidence supports that magnesium supplementation (mainly magnesium sulfate and magnesium oxide) prevents or treats various types of disorders or diseases related to respiratory system, reproductive system, nervous system, digestive system, and cardiovascular system as well as kidney injury, diabetes and cancer. The ongoing pandemic coronavirus disease 19 (COVID-19) characterized by respiratory tract symptoms with different degrees of important organ and tissue damages has attracted global attention. Particularly, effective drugs are still lacking in the COVID-19 therapy. In this review, we find and summarize the effectiveness of magnesium supplementation on the disorders or diseases, and provide a reference to the possibility of magnesium supplementation for supportive treatment in patients with COVID-19.
镁作为一种酶激活剂，对于各种生理功能是必不可少的，如细胞周期、代谢调节、肌肉收缩和血管舒缩。越来越多的证据表明，镁补充剂（主要是硫酸镁和氧化镁）可预防或治疗与呼吸系统、生殖系统、神经系统、消化系统和心血管系统以及肾损伤、糖尿病和癌症相关的各种类型的疾病或病症。当前的大流行冠状病毒病 19（COVID-19）以呼吸道症状为特征，伴有不同程度的重要器官和组织损伤，引起了全球关注。特别是，COVID-19 治疗中仍然缺乏有效的药物。在这篇综述中，我们发现并总结了镁补充剂对这些疾病或病症的治疗效果，为 COVID-19 患者的支持性治疗中镁补充剂的可能性提供了参考。
