Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R Street, Detroit, MI 48201, USA.
Endocr Relat Cancer. 2010 Aug 16;17(3):R195-212. doi: 10.1677/ERC-10-0074. Print 2010 Sep.
Among many endocrine-related cancers, prostate cancer (PCa) is the most frequent male malignancy, and it is the second most common cause of cancer-related death in men in the United States. Therefore, this review focuses on summarizing the knowledge of molecular signaling pathways in PCa because, in order to better design new preventive strategies for the fight against PCa, documentation of the knowledge on the pathogenesis of PCa at the molecular level is very important. Cancer cells are known to have alterations in multiple cellular signaling pathways; indeed, the development and the progression of PCa are known to be caused by the deregulation of several selective signaling pathways such as the androgen receptor, Akt, nuclear factor-kappaB, Wnt, Hedgehog, and Notch. Therefore, strategies targeting these important pathways and their upstream and downstream signaling could be promising for the prevention of PCa progression. In this review, we summarize the current knowledge regarding the alterations in cell signaling pathways during the development and progression of PCa, and document compelling evidence showing that these are the targets of several natural agents against PCa progression and its metastases.
在众多与内分泌相关的癌症中，前列腺癌（PCa）是男性最常见的恶性肿瘤，也是美国男性癌症相关死亡的第二大主要原因。因此，本综述重点总结了 PCa 中分子信号通路的知识，因为为了更好地设计针对 PCa 的新预防策略，记录 PCa 发病机制的分子水平的知识非常重要。众所周知，癌细胞中存在多个细胞信号通路的改变；事实上，PCa 的发展和进展是由多个选择性信号通路的失调引起的，如雄激素受体、Akt、核因子-κB、Wnt、Hedgehog 和 Notch。因此，针对这些重要通路及其上下游信号的策略可能对预防 PCa 进展有很大的希望。在本综述中，我们总结了目前关于 PCa 发生和发展过程中细胞信号通路改变的知识，并提供了有力的证据表明，这些是几种天然药物针对 PCa 进展及其转移的靶点。
