Singla Rajeev K, Sharma Pooja, Dubey Ankit Kumar, Gundamaraju Rohit, Kumar Dinesh, Kumar Suresh, Madaan Reecha, Shri Richa, Tsagkaris Christos, Parisi Salvatore, Joon Shikha, Singla Shailja, Kamal Mohammad Amjad, Shen Bairong
Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
iGlobal Research and Publishing Foundation, New Delhi, India.
Front Pharmacol. 2021 Oct 19;12:732266. doi: 10.3389/fphar.2021.732266. eCollection 2021.
With prostate cancer being the fifth-greatest cause of cancer mortality in 2020, there is a dire need to expand the available treatment options. Castration-resistant prostate cancer (CRPC) progresses despite androgen depletion therapy. The mechanisms of resistance are yet to be fully discovered. However, it is hypothesized that androgens depletion enables androgen-independent cells to proliferate and recolonize the tumor. Natural bioactive compounds from edible plants and herbal remedies might potentially address this need. This review compiles the available cheminformatics-based studies and the translational studies regarding the use of natural products to manage CRPC. PubMed and Google Scholar searches for preclinical studies were performed, while ClinicalTrials.gov and PubMed were searched for clinical updates. Studies that were not in English and not available as full text were excluded. The period of literature covered was from 1985 to the present. Our analysis suggested that natural compounds exert beneficial effects due to their broad-spectrum molecular disease-associated targets. and studies revealed several bioactive compounds, including rutaecarpine, berberine, curcumin, other flavonoids, pentacyclic triterpenoids, and steroid-based phytochemicals. Molecular modeling tools, including machine and deep learning, have made the analysis more comprehensive. Preclinical and clinical studies on resveratrol, soy isoflavone, lycopene, quercetin, and gossypol have further validated the translational potential of the natural products in the management of prostate cancer.
前列腺癌是2020年癌症死亡的第五大原因，因此迫切需要扩大可用的治疗选择。去势抵抗性前列腺癌（CRPC）尽管进行了雄激素剥夺治疗仍会进展。其耐药机制尚未完全发现。然而，据推测，雄激素剥夺使雄激素非依赖性细胞增殖并重新在肿瘤中定植。来自可食用植物和草药的天然生物活性化合物可能满足这一需求。本综述汇编了基于化学信息学的现有研究以及关于使用天然产物治疗CRPC的转化研究。在PubMed和谷歌学术上搜索了临床前研究，同时在ClinicalTrials.gov和PubMed上搜索了临床更新情况。排除了非英文且无全文的研究。所涵盖的文献时间段为1985年至今。我们的分析表明，天然化合物因其广泛的分子疾病相关靶点而发挥有益作用。研究还揭示了几种生物活性化合物，包括吴茱萸次碱、黄连素、姜黄素、其他黄酮类化合物、五环三萜类化合物和甾体类植物化学物质。包括机器学习和深度学习在内的分子建模工具使分析更加全面。对白藜芦醇、大豆异黄酮、番茄红素、槲皮素和棉酚的临床前和临床研究进一步验证了天然产物在前列腺癌治疗中的转化潜力。
