Janin A, Piette J C, Courtin P
Laboratoire d'Anatomie Pathologique C, Hôpital Calmette, Lille.
Rev Rhum Mal Osteoartic. 1991 Apr;58(4):283-6.
Atrophic polychondritis (APC) results from elective lesions of the components of elastic cartilage. Clinical criteria have been established in terms of the incidence of auricular, nasal, ocular, tracheobronchial or cochlear involvement. However, recent clinical and pathological reviews have shown the frequency and severity of vascular lesions, aortic as well as peripheral. Several pathological mechanisms probably participate together in the destruction of elastic cartilage. A direct enzyme abnormality of glycoaminoglycanes and of elastic tissue are believed to be interlinked with an auto-immune process bringing type II anticollagen antibodies into play.
萎缩性多软骨炎(APC)是由弹性软骨成分的选择性损伤引起的。已根据耳廓、鼻、眼、气管支气管或耳蜗受累的发生率制定了临床标准。然而,最近的临床和病理综述显示了血管病变的频率和严重程度,包括主动脉以及外周血管。几种病理机制可能共同参与弹性软骨的破坏。糖胺聚糖和弹性组织的直接酶异常被认为与激活II型抗胶原蛋白抗体的自身免疫过程相互关联。