Department of Periodontology, School of Dentistry, Ege University, Bornova, 35100, İzmir, Turkey.
Inflammation. 2011 Jun;34(3):203-8. doi: 10.1007/s10753-010-9225-0.
This study was planned to investigate whether chronic periodontitis patients exhibit different plasma concentrations of C-telopeptide pyridinoline cross-links of type I collagen (ICTP) and osteocalcin (OC) compared to the clinically healthy controls. Before initiation of any periodontal intervention, plasma samples and full-mouth clinical periodontal recordings were obtained from 58 otherwise healthy patients with chronic periodontitis and also from 47 systemically and periodontally healthy control subjects. Plasma ICTP levels were determined by radioimmunoassay and OC levels by enzyme-linked immunosorbent assay. Data were tested statistically using t test and ANOVA. The healthy control group exhibited significantly lower values in all clinical periodontal measurements (P < 0.001). There were no significant differences between the study groups in plasma ICTP and OC levels (P > 0.05). Within the limits of this study, it may be suggested that plasma levels of ICTP and OC may not provide distinguishing data between chronic periodontitis patients and clinically healthy subjects.
本研究旨在探讨与临床健康对照组相比，慢性牙周炎患者的 I 型胶原 C 端肽吡啶交联（ICTP）和骨钙素（OC）的血浆浓度是否存在差异。在开始任何牙周干预之前，从 58 名患有慢性牙周炎的其他健康患者和 47 名系统性和牙周健康的对照者中获得了血浆样本和全口临床牙周记录。通过放射免疫测定法测定血浆 ICTP 水平，通过酶联免疫吸附测定法测定 OC 水平。使用 t 检验和方差分析对数据进行统计学检验。健康对照组在所有临床牙周测量中均表现出显著较低的值（P<0.001）。研究组之间的血浆 ICTP 和 OC 水平无显著差异（P>0.05）。在本研究的范围内，可以认为 ICTP 和 OC 的血浆水平可能无法为慢性牙周炎患者和临床健康受试者提供区分数据。
