Yoshihara A, Deguchi T, Hanada N, Miyazaki H
Division of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Oral Dis. 2009 Mar;15(2):176-81. doi: 10.1111/j.1601-0825.2008.01511.x.
The purpose of this study was to evaluate the relation of bone turnover markers such as bone formation and resorption to periodontal disease and jaw bone morphology in elderly Japanese subjects.
We selected 148 subjects for participation in this study. All subjects were aged 77 years. The periodontal examination included the assessment of clinical attachment level (CAL). Biochemical parameters of bone turnover measured included urinary deoxypyridinoline, serum osteocalcin (S-OC), and serum bone-specific alkaline phosphatase. In addition, to evaluate the jawbone, we used the mandibular inferior cortex classification (MIC).
Serum osteocalcin had significantly higher (males: P = 0.038, females: P = 0.041) tendency for MIC Class (ANOVA). Multiple linear regression results showed that the number of remaining teeth and S-OC were negatively associated with the percentage of sites with > or =6 mm CAL (R(2) = 0.322, P < 0.001). Coefficients and betas were -0.71, -0.46 (P < 0.001) and -1.11, -0.28 (P = 0.002), respectively.
In conclusion, this study suggests that there is a significant relation of bone turnover markers to periodontal disease and jaw bone morphology in elderly Japanese subjects.
本研究旨在评估老年日本受试者中骨形成和骨吸收等骨转换标志物与牙周疾病及颌骨形态之间的关系。
我们选取了148名受试者参与本研究。所有受试者均为77岁。牙周检查包括临床附着水平（CAL）评估。所测量的骨转换生化参数包括尿脱氧吡啶啉、血清骨钙素（S-OC）和血清骨特异性碱性磷酸酶。此外，为评估颌骨，我们采用了下颌骨皮质下分类（MIC）。
血清骨钙素在MIC分类方面具有显著更高（男性：P = 0.038，女性：P = 0.041）的趋势（方差分析）。多元线性回归结果显示，剩余牙齿数量和S-OC与CAL≥6mm部位的百分比呈负相关（R² = 0.322，P < 0.001）。系数和β值分别为-0.71、-0.46（P < 0.001）和-1.11、-0.28（P = 0.002）。
总之，本研究表明在老年日本受试者中骨转换标志物与牙周疾病及颌骨形态之间存在显著关系。
