Bullon Pedro, Goberna Berta, Guerrero Juan M, Segura Juan J, Perez-Cano Ramon, Martinez-Sahuquillo Angel
Periodontics Department, School of Dentistry, University of Seville, Spain.
J Periodontol. 2005 Apr;76(4):513-9. doi: 10.1902/jop.2005.76.4.513.
Periodontitis and osteoporosis are characterized by the loss of bone mass. Osteocalcin levels have been postulated as a marker of inhibition of bone formation. The aim of the present study was to assess plasma, saliva, and gingival crevicular fluid (GCF) levels of osteocalcin and correlate them with periodontitis and osteoporosis.
Seventy-three postmenopausal women, over 35 years old, were recruited for the study. Serum, saliva, and GCF osteocalcin were measured. Vertebral bone mineral density was measured by dual-energy x-ray absorptiometry. Differences between groups were assessed by analysis of variance (ANOVA), chi-square test, and non-parametric Kruskal-Wallis test.
Thirty-four (46.6%) were classified in the normal healthy bone group, 11 women (15.1%) in the osteopenic group, and 28 women (38.4%) in the osteoporotic group. No statistically significant differences between these densitometric groups were observed in probing depth (P = 0.24); clinical attachment level (P = 0.11); or mean osteocalcin concentrations in serum, saliva, and GCF. Twenty-seven (37.0%) of the women were classified without periodontitis (NPG) and 63.0% (N = 46) with periodontal disease (PG). There were no statistical differences in serum and saliva osteocalcin concentrations between these two groups. GCF osteocalcin concentrations were significantly higher in the PG women than in the NPG group (P = 0.008). Mean probing depth correlated significantly with GCF osteocalcin concentrations (r = 0.35; P = 0.002).
The results further support the concept that osteocalcin levels in GCF correlates with periodontal but not with osteoporosis status.
牙周炎和骨质疏松症的特征是骨量流失。骨钙素水平被认为是抑制骨形成的标志物。本研究的目的是评估血浆、唾液和龈沟液（GCF）中骨钙素的水平，并将它们与牙周炎和骨质疏松症相关联。
招募了73名35岁以上的绝经后女性参与本研究。测量血清、唾液和GCF中的骨钙素。通过双能X线吸收法测量椎体骨密度。通过方差分析（ANOVA）、卡方检验和非参数Kruskal-Wallis检验评估组间差异。
34名（46.6%）被归类为正常健康骨组，11名女性（15.1%）为骨量减少组，28名女性（38.4%）为骨质疏松组。在这些骨密度测量组之间，在探诊深度（P = 0.24）、临床附着水平（P = 0.11）或血清、唾液和GCF中的平均骨钙素浓度方面未观察到统计学上的显著差异。27名（37.0%）女性被归类为无牙周炎（NPG），63.0%（N = 46）患有牙周疾病（PG）。这两组之间血清和唾液骨钙素浓度没有统计学差异。PG女性的GCF骨钙素浓度显著高于NPG组（P = 0.008）。平均探诊深度与GCF骨钙素浓度显著相关（r = 0.35；P = 0.002）。
结果进一步支持了GCF中骨钙素水平与牙周炎相关但与骨质疏松状态无关的概念。
