Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, Korea.
Int J Hematol. 2010 Jul;92(1):45-51. doi: 10.1007/s12185-010-0619-4. Epub 2010 Jun 25.
Both stem cells and progenitor cells are present in umbilical cord blood (UCB) at a high frequency, making these cells a major target population for experimental and clinical studies. As the use of autologous or allogeneic hematopoietic stem cell transplantation in the treatment of various diseases has grown rapidly in recent years, the concept of UCB banking for future use has drawn increasing interest. Stem and progenitor cells derived from UCB offer multiple advantages over adult stem cells, such as their immaturity (which may play a significant role in reducing rejection after transplantation into a mismatched host) and ability to produce large quantities of homogeneous tissue or cells. These cells can also differentiate across tissue lineage boundaries into neural, cardiac, epithelial, hepatic, and dermal tissues. Human UCB provides an alternative cell source that is ethically acceptable and widely supported by the public. This paper summarizes the characteristics of human UCB-derived stem and progenitor cells and their potential therapeutic use for tissue and cell regeneration.
脐带血（UCB）中存在大量的干细胞和祖细胞，使其成为实验和临床研究的主要目标人群。近年来，自体或同种异体造血干细胞移植在治疗各种疾病中的应用迅速增长，因此人们对未来使用 UCB 进行存储的概念越来越感兴趣。与成人干细胞相比，UCB 中的干细胞和祖细胞具有多种优势，例如其不成熟性（这可能在降低移植到不匹配宿主后的排斥反应方面发挥重要作用）和产生大量同质组织或细胞的能力。这些细胞还可以跨组织谱系界限分化为神经、心脏、上皮、肝脏和皮肤组织。人 UCB 提供了一种替代的细胞来源，在伦理上是可以接受的，并且得到了公众的广泛支持。本文总结了人 UCB 来源的干细胞和祖细胞的特征及其在组织和细胞再生方面的潜在治疗用途。
