Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P R China.
Planta Med. 2010 Aug;76(11):1037-43. doi: 10.1055/s-0030-1250073. Epub 2010 Jun 24.
Natural products, especially microtubule-binding natural products, play important roles in the war against cancer. From the clinical use of vinblastine in 1961, paclitaxel in 1992, to ixabepilone in 2007, microtubule-binding natural products have continually contributed to the development of cancer therapy. The present review summarizes the development of representative microtubule-binding natural products including agents binding to the colchicine-binding site, the VINCA alkaloid-binding site, the taxane-binding site and other binding sites. Future directions for the development of new anticancer microtubule-binding natural products are discussed. Finding new formulations, new targets and new sources of microtubule-binding natural products may enable more members of this kind of agent to be introduced into the clinic for cancer therapy.
天然产物，尤其是微管结合的天然产物，在抗癌斗争中发挥着重要作用。从 1961 年长春碱的临床应用、1992 年紫杉醇到 2007 年伊沙匹隆，微管结合的天然产物不断为癌症治疗的发展做出贡献。本综述总结了具有代表性的微管结合天然产物的开发，包括与秋水仙碱结合部位、长春花生物碱结合部位、紫杉烷结合部位和其他结合部位结合的药物。讨论了开发新的抗癌微管结合天然产物的未来方向。寻找新的制剂、新的靶点和微管结合天然产物的新来源，可能使更多此类药物进入临床用于癌症治疗。
