Ben Gurion University of the Negev, Bioinformatic Core Facility, National Institute of Biotechnology in the Negev, Beer Sheva, Israel.
Planta Med. 2010 Nov;76(16):1847-51. doi: 10.1055/s-0030-1250061. Epub 2010 Jun 24.
α-Hederin, a natural triterpene saponin and its derivative kalopanaxsaponin I (ksI) exhibit cytotoxicity against various cancer cell lines and IN VIVO tumors. We studied the genetic variants contributing to the activity of these two anticancer compounds. Cell lines derived from 30 trios of European descent (Centre d'Etude du Polymorphisme Human, CEPH; CEU) and 30 trios of African descent (Yoruban, YRI) were used. Cytotoxicity was determined as inhibition of cell growth at increasing concentrations of α-hederin or ksI for 24 h. In comparison to the European, the Yoruban populations revealed a higher sensitivity to α-hederin and to ksI that can be attributed to several unique SNPs. These SNPs are located near 111 and 130 genes in the European and the Yoruban populations, respectively, raising the possibility that some of these genes contribute to the differential sensitivity to these compounds.
α-常春藤苷，一种天然的三萜皂苷及其衍生物高丽参皂苷 I（ksI），对多种癌细胞系和体内肿瘤均具有细胞毒性。我们研究了导致这两种抗癌化合物活性的遗传变异。使用了源自 30 对欧洲血统（人类多态性研究中心，CEPH；CEU）和 30 对非洲血统（约鲁巴人，YRI）的细胞系。细胞毒性通过在 24 小时内用α-常春藤苷或 ksI 的递增浓度抑制细胞生长来确定。与欧洲人群相比，约鲁巴人群对 α-常春藤苷和 ksI 的敏感性更高，这归因于几个独特的 SNP。这些 SNP 分别位于欧洲和约鲁巴人群中的 111 和 130 个基因附近，这增加了这些基因中某些基因可能对这些化合物的敏感性差异有贡献的可能性。
